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Dr. Hidetaka Ohnuki, LCO Staff Scientist Profile Photo

Hidetaka Ohnuki, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Ohnuki’s research focuses on molecular mechanisms in angiogenesis and hematopoiesis. Recently, he developed a single-cell method for iterative epigenomic analyses in the same single cells. He applies the single-cell technology to research on perivascular niches in physiological hematopoiesis and in the context of oncogenesis and cancer evolution.

Areas of Expertise

1) single cell epigenomics 2) vascular biology 3) tumor angiogenesis 4) peri-vascular niches 5) molecular biology 6) gene regulatory networks

Publications

Selected Key Publications

Iterative Epigenomic Analyses in the Same Single Cell.

Ohnuki H., Venzon D.J., Lobanov A., Tosato G
Genome Res.. 31: 1819-1830, 2021.
Full-Text Article
[ Journal Article ]

Reusable Single Cell for Iterative Epigenomic Analyses

Ohnuki H., Venzon D.J., Lobanov A., Tosato G
J. Vis. Exp.. 180: 2022.
Full-Text Article
[ Journal Article ]

EphrinB2 controls vessel pruning through STAT1-JNK3 signalling

Salvucci O.(*), Ohnuki H.(*), Maric D., Hou X., Li X., Yoon S.O., Segarra M., Eberhart C.G., Acker-Palmer A., Tosato G
Nat. Commun.. 6:6576: 2015.
Full-Text Article
[ Journal Article ]

Semaphorin 6A regulates angiogenesis by modulating VEGF signaling

Segarra M.(*), Ohnuki H. (*), Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G
Blood. 120(19): 4104-15, 2012.
Full-Text Article
[ Journal Article ]

BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis

Ohnuki, H., Inoue, H., Takemori, N., Nakayama, H., Sakaue, T., Fukuda, S., Miwa, D., Nishiwaki, E., Hatano, M., Tokuhisa, T., Endo, Y., Nose, M., Higashiyama, S
Blood. 119(11): 2688-2698, 2012.
Full-Text Article
[ Journal Article ]