Diana Monteiro

Diana C.F. Monteiro, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Structural Biology


I am a protein crystallographer focused on molecular mechanisms and protein dynamics. My group develops and employs new methods to obtain high-resolution structures of medically-relevant proteins, including room-temperature, serial and time-resolved crystallography. We also determine protein-ligand structures to link to medicinal chemistry efforts, both with pre-determined binders and through high-throughput small molecule screening.

Areas of Expertise


Selected Key Publications

Using photocaging for fast time- resolved structural biology studies

Monteiro DCF, Amoah E, Rogers C, Pearson AR.
Acta Crystallogr D Struct Biol. 77(Pt 10): 1218-1232, 2021.

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

Monteiro DCF, von Stetten D, Stohrer C, Sans M, Pearson AR, Santoni G, van der Linden P, Trebbin M.
IUCrJ. 7(Pt 2): 207-219, 2020. [ Journal Article ]

Photocage-initiated time-resolved solution X-ray scattering investigation of protein dimerization

Josts I, Niebling S, Gao Y, Levantino M, Tidow H, Monteiro D.
IUCrJ. 5(Pt 6): 667-672, [ Journal Article ]

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schlünzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A.
Science. 372(6542): 642-646, 2021. [ Journal Article ]

Homogeneous batch micro-crystallization of proteins from ammonium sulfate

Stohrer C, Horrell S, Meier S, Sans M, von Stetten D, Hough M, Goldman A, Monteiro DCF, Pearson AR.
Acta Crystallogr D Struct Biol. 77(Pt 2): 194-204, 2021. [ Journal Article ]

Job Vacancies

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