Job Description
The Monteiro Research Group at the Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health in Frederick Maryland is searching for a postdoctoral fellow in the field of high-throughput fragment screening. Initial applications will be evaluated starting August 15th and the search will remain open until the position is filled. The successful candidate will be expected to start in Fall 2025. Initial appointment is for two years, with the possibility of extension to five.
The Monteiro lab specializes in protein crystallography to drive drug discovery and development, using high-throughput structure and validation pipelines. Our team is highly interdisciplinary, working at the interface between protein crystallography and medicinal chemistry. Current drug targets focus on oncometabolic pathways.
The postdoctoral fellow will work in fragment screening, using high-throughput crystallization and compound soaking techniques, to determine structure-activity relationships. The work will also encompass in silico modeling, molecular dynamics and the development of novel approaches to interface with natural product screening.
We are looking for enthusiastic and dedicated scientists to join our team. Due to the nature of the work, all candidates are expected to have excellent communication skills and enjoy working in multidisciplinary teams and projects. The NIH Intramural Program also provides excellent training and career development opportunities.
Qualifications and Job Details
Required and Preferred Skills
- Ph.D. in structural biology (or similar) at the time of appointment, obtained in the last five years (exceptions possible)
- Experience in protein-ligand modeling, including docking software
- Protein expression and purification from bacterial hosts
- Protein crystallization and X-ray data collection, reduction and analysis
- Protein activity and binding assays
- Strong writing, editing and presentation skills
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.
Applicants should send a CV, cover letter and the names of three referees to Dr. Diana Monteiro: diana.monteiro@nih.gov. Please ensure that the cover letter addresses previous research experience, career goals and reason for application to this specific position. Informal enquiries are welcome. More information can be found on my website.