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Colin C. C. Wu, Ph.D.

Colin C. C. Wu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 560, Room 21-102C
  • Frederick, MD, 21702-1201
  • 301.846.7683
  • colin.wu2@nih.gov
RNA Biology Laboratory

RESEARCH SUMMARY

We are exploring the role of the ribosome in stress response signaling pathways and translational regulation in mammalian systems. To this end, we have developed an improved ribosome footprint profiling methodology that allows us to monitor both the positions and the in vivo functional states of individual ribosomes. Most projects in the laboratory incorporate high-throughput genome-wide approaches, computational tools, and biochemical approaches to define the molecular mechanisms of these pathways in vivo. Our long-term goal aims to congregate actionable insights that can be used to guide the prevention and treatment of human diseases.

Areas of Expertise

1) translational control, 2) ribosome, 3) RNA quality control, 4) RNA biology, 5) protein synthesis

Publications

Selected Recent Publications

Ribosome collisions trigger general stress responses to regulate cell fate

Wu CC, Peterson A, Zinshteyn B, Regot S, Green R.
Cell. 182(2): 404-416, 2020. [ Journal Article ]

High-resolution ribosome profiling defines discrete ribosome elongation states and translational regulation during cellular stress

Wu CC, Zinshteyn B, Wehner KA, Green R.
Mol Cell. 73(3): 959-970, 2019. [ Journal Article ]

eIF5A functions globally in translation elongation and termination

Schuller AP*, Wu CC*, Dever TE, Buskirk AR, Green R. (* Co-first authors)
Mol Cell. 66(2): 194-205, 2017. [ Journal Article ]

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.

Ranjan N*, Pochopien AA*, Wu CC*, Beckert B, Blanchet S, Green R, Rodnina MV & Wilson DN. (* Co-first authors)
EMBO J.. e106449: 2021. [ Journal Article ]

High-Resolution Ribosome Profiling for Determining Ribosome Functional States During Translation Elongation

Shafieinouri M, Santiago Membréno B, Wu CC
Methods in Molecular Biology. 2428: 2022. [ Book Chapter ]

Job Vacancies

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