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Colin C. C. Wu, Ph.D.

Colin C. C. Wu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 560, Room 21-102C
  • Frederick, MD, 21702-1201
  • 301.846.7683
  • colin.wu2@nih.gov
Stadtman Investigator
RNA Biology Laboratory
Head, Translational Control of Gene Expression Section

RESEARCH SUMMARY

We are exploring the role of the ribosome in stress response signaling pathways and translational regulation in mammalian systems. To this end, we have developed an improved ribosome footprint profiling methodology that allows us to monitor both the positions and the in vivo functional states of individual ribosomes. Most projects in the laboratory incorporate high-throughput genome-wide approaches, computational tools, and biochemical approaches to define the molecular mechanisms of these pathways in vivo. Our long-term goal aims to congregate actionable insights that can be used to guide the prevention and treatment of human diseases.

Areas of Expertise

Translational Control
Ribosome
rRNA Quality Control
Protein Synthesis

Publications

Selected Key Publications

The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

Coria AR, Shah A, Shafieinouri M, Taylor SJ, Guiblet W, Miller JT, Sharma IM, Wu CC
bioRxiv. 2024. [ Journal Article ]

Transfer RNA acetylation regulates in vivo mammalian stress signaling

Gamage S T*, Khoogar R*, Manage SH, Crawford MC, Georgeson J, Sanders C, Polevoda BV, Tripu DR, Nance K, Perez M, Thu CT, Evans C, Holewinski R, Meyer T, Yang A, Jailwala P, Nguyen JT, Andressen T, Mock BA, Gu S, Edmundson E, Difilippantonio S, Chari R, Schwartz S, O’Connell MR#; Wu CC#, Meier JL# (* co-first authors; # co-corresponding authors)
bioRxiv. 2024. [ Journal Article ]

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.

Ranjan N*, Pochopien AA*, Wu CC*, Beckert B, Blanchet S, Green R, Rodnina MV & Wilson DN. (* co-first authors)
EMBO J.. e106449: 2021. [ Journal Article ]

Ribosome collisions trigger general stress responses to regulate cell fate

Wu CC, Peterson A, Zinshteyn B, Regot S, Green R.
Cell. 182(2): 404-416, 2020. [ Journal Article ]

High-resolution ribosome profiling defines discrete ribosome elongation states and translational regulation during cellular stress

Wu CC, Zinshteyn B, Wehner KA, Green R.
Mol Cell. 73(3): 959-970, 2019. [ Journal Article ]

Job Vacancies

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Team

Aaztli
Postdoctoral Fellow (CRTA)
Aaztli Coria, Ph.D.
Akruti
Postdoctoral Fellow (Visiting)
Akruti Shah, Ph.D.
Emilien
Postdoctoral Fellow (CRTA)
Emilien Orgebin, Ph.D.

News

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