Breadcrumb

Chongyi Chen, Ph.D.

Chongyi Chen, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

The Chen lab investigates the topological tension of DNA, known as DNA supercoiling, and its primary modulator, DNA topoisomerase, a key target in cancer chemotherapy. Leveraging our expertise in developing novel genomic technologies and single-cell assays, we explore how DNA supercoiling and topoisomerases interact with chromatin organization, regulating gene expression and contributing to genome instability in human cells. Our research aims to uncover the regulatory mechanisms and functional consequences of DNA supercoiling and topoisomerases in genome dynamics across various biological and biomedical processes. The long-term goal is to translate our discoveries in DNA topology and chromatin biology, along with our advanced genomic and single-cell methodologies, into breakthroughs in cancer research and medicine.

Areas of Expertise

DNA Supercoiling and Topoisomerase
Chromatin Organization
Gene Expression
Genomic Technology and Single-cell Assay Development

Publications

Selected Publications

Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression

Yao Q, Zhu L, Shi Z, Banerjee S, Chen C.
Nature Structural & Molecular Biology. 2024. [ Journal Article ]

A convenient single-cell newly synthesized transcriptome assay reveals gene expression dynamics during early-stage T-cell activation

Lyu J, Xu X, Chen C.
bioRxiv. 2024.
Full-Text Article
[ Journal Article ]

DNA topology: A central dynamic coordinator in chromatin regulation

Li S, Vemuri C, Chen C.
Current Opinion in Structural Biology. 87: 102868, 2024. [ Journal Article ]

Single-cell Whole-genome Analyses by Linear Amplification via Transposon Insertion (LIANTI)

Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, Xie XS.
Science. 356: 189-194, 2017. [ Journal Article ]

Job Vacancies

We have no open positions in our group at this time, please check back later.

To see all available positions at CCR, take a look at our Careers page. You can also subscribe to receive CCR's latest job and training opportunities in your inbox.

Team

Qian Yao
Postdoctoral Fellow (Visiting)
Qian Yao, Ph.D.
Jun Lyu
Postdoctoral Fellow (Visiting)
Jun Lyu, Ph.D.
Linying Zhu
Postdoctoral Fellow (Visiting)
Linying Zhu, Ph.D.
Shuai Li
Post-doctoral Fellow (Visiting)
Shuai Li, Ph.D.
Charan_profile
Postbaccalaureate (CRTA)
Charan Vemuri

News

Learn more about CCR research advances, new discoveries and more
on our news section.