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Chongyi Chen, Ph.D.

Chongyi Chen, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

The Chen lab study chromatin structure, DNA topology, and gene expression regulation in human cells, by newly invented genomic technologies and single-cell assays. We seek to understand how the topological tension of the double helix interacts with other chromatin features during fundamental biological processes. The lab also develops new techniques in single-cell genomics, epigenomics, and transcriptomics. The long-term goal is to apply the new knowledge in chromatin biology and the new methodologies in single-cell omics to cancer biology and medicine.

Areas of Expertise

1) chromatin structure 2) DNA topology 3) gene expression 4) single-cell and genomic technology development 5) single-molecule imaging

Publications

Selected Key Publications

Neuronal enhancers are hotspots for DNA single-strand break repair

Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A.
Nature. 593: 440-444, 2021. [ Journal Article ]

Single cell genomics to study DNA and chromosome changes in human gametes and embryos

Blanshard RC, Chen C, Xie XS, Hoffmann ER.
Methods in Cell Biology. 144: 441-457, 2018. [ Journal Article ]

Single-cell Whole-genome Analyses by Linear Amplification via Transposon Insertion (LIANTI)

Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, Xie XS.
Science. 356: 189-194, 2017. [ Journal Article ]

Mechanism of Transcriptional Bursting in Bacteria

Chong S, Chen C, Ge H, Xie XS.
Cell. 158: 314-326, 2014. [ Journal Article ]

Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria

Wang W, Li G, Chen C, Xie XS, Zhuang X
Science. 333: 1445-1449, 2011. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (Visiting)
Jun Lyu, Ph.D.
Postdoctoral Fellow (Visiting)
Qian Yao, Ph.D.
Postdoctoral Fellow (Visiting)
Linying Zhu, Ph.D.
Post-doctoral Fellow (Visiting)
Shuai Li, Ph.D.

Alumni

Yun Shen
Yun Shen, Assistant Professor, UC Riverside
2019-2022
Guest Researcher