Charalampos “Harris” S. Floudas, MD, DMSc, MS
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 13N240
- Bethesda, MD, 20892
- 240-858-3032
- charalampos.floudas@nih.gov
RESEARCH SUMMARY
Dr Floudas is a Board Certified Medical Oncologist specializing in Head and Neck Cancer (HNC). He is clinically active in drug development for HNC, designing and conducting bench-to-bedside early-phase investigator-initiated clinical trials of immunotherapy and complex biologics.
Current clinical trials are addressing primarily mucosal Squamous Cell Cancer of the Head and Neck (HNSCC/SCCHN) in the recurrent/metastatic but also in the curative setting, as well as rare cancers of the Head and Neck, such as Olfactory Neuroblastoma (esthesioneuroblastoma) and Sinonasal Undifferentiated Carcinoma (SNUC).
His translational research interests include machine learning (AI?ML) analysis of multimodal omics for biomarker discovery and to resolve questions in tumor immunology, such as the complex topography and interactions shaping the tumor microenvironment.
Dr Floudas is also exploring the applications of LLMs in Oncology, particularly looking at increasing the efficiency of clinical trial workflows, including patient-clinical trial matching.
Areas of Expertise
Information for Patients
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Charalampos “Harris” S. Floudas, MD, DMSc, MS
Clinical Trials
Research
Dr Floudas’ research focuses in head and neck cancer and tumor immunology. He is working closely with the scientists of the Center for Immuno-Oncology and the Otolaryngology Surgeon-Scientists of the NCI Surgical Oncology Program, and is studying novel combinations of immunotherapeutic agents aiming to improve the efficacy of immunotherapy in head and neck cancers.
Publications
Biography
Charalampos “Harris” S. Floudas, MD, DMSc, MS
Dr. Floudas received his medical degree from the University of Crete, Greece, (MD, 2000), and completed an Internal Medicine residency at the University of Athens, Greece (2008), from which he received a research doctorate in medicine (DMSc, 2009) while serving as an Oncology Research Associate.
Subsequently, he studied Biomedical Informatics in the University of Pittsburgh (MS, 2012), and was a visiting research scholar in the Center for Health and Biomedical Informatics of the New York University (2013).
Following Internal Medicine residency (Maimonides Medical Center, Brooklyn, NY, 2016), he graduated from the NIH Hematology Oncology Fellowship (2019) and joined the NCI Genitourinary Malignancies Branch to develop a Head and Neck Cancer program, moving to the Center for Immuno-Oncology in May 2022.
