Breadcrumb

Avinash Bhandoola, M.B., B.S., Ph.D.

Avinash Bhandoola, M.B., B.S., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity

RESEARCH SUMMARY

T cells play essential roles in immune responses. They originate from blood stem cells in the bone marrow, but their development completes at a distinct anatomical site, the thymus. We're interested in the mechanisms by which some hematopoietic progenitor cells migrate to the thymus, and in the transcriptional mechanisms in the thymus that direct the earliest thymus colonizing progenitors down the T cell lineage. We hope to understand the regulatory and developmental logic that establishes a functioning immune system.

Areas of Expertise

1) transcription factors that establish and maintain T cell identity 2) T cell regeneration and bone marrow transplantation 3) thymic epithelial cells

Publications

Selected Key Publications

Switch hitter: Bcl11b in T cells and ILC2s

Harly C, Bhandoola A.
J Exp Med. 217(1): e20191739, 2020. [ Journal Article ]

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Cowan JE, Malin J, Zhao Y, Seedhom MO, Harly C, Ohigashi I, Kelly M, Takahama Y, Yewdell JW, Cam M, Bhandoola A.
Nat Commun.. 10(1): 5498, 2019. [ Journal Article ]

The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage

Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A.
Nat Immunol. 20(9): 1150-60, 2019. [ Journal Article ]

A novel role for p53 in self-tolerance

Larsen BM, Bhandoola A
Blood. 130(4): 388-89, 2017. [ Journal Article ]

TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow

Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, Wang H, Wang X, Yu S, Zhou X, Cam M, Xue HH, Bhandoola A.
Nat Immunol. 16(10): 1044-50, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - T cell development, regeneration Ph.D. or equivalent Avinash Bhandoola avinash.bhandoola@nih.gov

Team

Postdoctoral Fellow (Visiting)
Arundhoti Das, Ph.D.
Biologist
Yongge Zhao, Ph.D.
Postdoctoral Fellow (Visiting)
Yi Ding, Ph.D.
Postdoctoral Fellow (CRTA)
Susannah Shissler, Ph.D.
POSTDOCTORAL FELLOW (VISITING)
Marieke Laevert, Ph.D.
Guest Researcher
Abigail Morales Sanchez, Ph.D.
Special Volunteer
Gustavo Ulises Martinez Ruiz
Postbaccalaureate (CRTA)
Nathan Swanbery