Marielle E. Yohe, M.D., Ph.D.

Marielle E. Yohe, M.D., Ph.D.
Physician-Scientist Early Investigator
Head, Molecular Signaling Section

Dr. Yohe is a physician scientist with a research focus on understanding how molecular signaling events contribute to epigenetic changes that ultimately result in the development and metastasis of pediatric cancers. Specifically, Dr. Yohe is actively engaged in translational research aimed at targeting signaling pathways downstream of small GTPases, such as RAS, in rhabdomyosarcoma and neuroblastoma.

Areas of Expertise

1) pediatric solid tumors, 2) small GTPase signaling, 3) epigenetics

Contact Info

Marielle E. Yohe, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10-CRC, Room 1-W-5817
Bethesda, MD 20892
Ph: 240-760-7436

More than 30% of all human malignancies are driven by mutant RAS isoforms. In addition to well characterized roles in malignant transformation and tumor progression, oncogenic RAS is also able to block differentiation within a cancer cell. We have previously shown that inhibiting the RAS-RAF-MEK-ERK MAP kinase pathway restores the differentiation of rhabdomyosarcoma cells by affecting the transcription of the master transcription factor, MYOG. Current laboratory projects include characterizing the effect of oncogenic RAS on the differentiation of neuroblastoma cells and identifying mechanisms by which rhabdomyosarcoma cells acquire resistance to MAP kinase pathway inhibitors. In addition, the laboratory is engaged in translational research aimed at identifying additional RAS-directed therapeutics for pediatric cancers.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Genetics and Genomics, Molecular Biology and Biochemistry, Molecular Pharmacology

Selected Key Publications

  1. Kowalczyk JT, Wan X, Hernandez ER, Luo R, Lyons GC, Wilson KM, Gallardo DC, Isanogle KA, Robinson CM, Mendoza A, Heske CM, Chen J-Q, Luo X, Kelly AE, Difilippantonio S, Robey RW, Thomas CJ, Sackett DL, Morrison DK, Randazzo PA, Miller Jenkins LM, Yohe ME
    Molecular Cancer Therapeutics . DOI: 10.1158/1535-7163.MCT-20-0525, 2020. [ Journal Article ]
  2. Yohe ME, Gryder BE, Shern JF, Song YK, Chou, H-C, Sindiri S, Mendoza A, Patidar R, Zhang X, Guha R, Butcher D, Isanogle KA, Robinson CM, Luo X, Chen J-Q, Walton A, Awasthi P, Edmondson EF, Difilippantonio S, Wei JS, Zhao K, Ferrer M, Thomas CJ, Khan J
    Science Translational Medicine. 10: 448, 2018. [ Journal Article ]
  3. Gryder BE, Yohe ME, Chou H-C, Zhang X, Song Y, Marques J, Schaefer B, Sen N, Patidar R, Wen X, Wei J, Guha R, Ferrer M, Lal-Nag M, Andresson T, Shern JF, Zhao K, Thomas CJ, and Khan J.
    Cancer Discovery. 7: 884-899, 2017. [ Journal Article ]
  4. Shern JF, Yohe ME and Khan J.
    Critical Reviews in Oncogenesis. 20: 227-243, 2015. [ Journal Article ]
  5. Chen L, Shern JF, Wei JS, Yohe ME, Song YK, Hurd L, Liao H, Catchpoole D, Skapek SX, Barr FG, Hawkins DS, and Khan J.
    PLoS Genetics. 11: e1005075, 2015. [ Journal Article ]

After completing her undergraduate work at Wellesley College, Dr. Yohe received her M.D. and Ph.D from the University of North Carolina at Chapel Hill. She did her graduate work in the laboratory of Dr. John Sondek in the Department of Pharmacology. In this work, she addressed how truncation of Dbl-family Rho guanine nucleotide exchange factors leads to their aberrant activation. She completed her internship and residency in pediatrics at Connecticut Children's Medical Center in Hartford, CT, followed by fellowship training at the combined National Cancer Institute - Johns Hopkins University Hematology/Oncology program. She did her postdoctoral work in the laboratory of Dr. Javed Khan in the Genetics Branch of the CCR.

Dr. Yohe is board certified in General Pediatrics (2013) and Pediatric Hematology/Oncology (2017). She is the recipient of an Alex's Lemonade Stand Foundation Young Investigator Award.

Name Position
Edjay Agustin Hernandez Postbaccalaureate Fellow (IRTA)
Xiaolin Wan M.D., Ph.D. Biologist