In the Spotlight
Landmark discovery: H2AX as a sensor of DNA damage
William Bonner’s curiosity about histones led to the discovery that the protein H2AX is altered in response to harmful DNA damage called a double-strand break. This powerful tool has led to breakthroughs in both basic and clinical cancer research.
Read MoreFDA grants orphan drug status to selumetinib for neurofibromatosis type 1 (NF1) treatment
The U.S. Food and Drug Administration granted orphan drug status in February to selumetinib for use in patients with the genetic disorder neurofibromatosis type 1 (NF1), who often develop tumors of the peripheral nervous system. Receiving orphan drug designation is a helpful step for selumetinib.
Read More