Chronic graft-versus-host disease (cGVHD) is an immune system disorder that can occur in people who have had a stem cell transplant. cGVHD can affect multiple organs and increase risk of disability and death, so new treatments are needed to treat this condition. A clinical trial led Noa G. Holtzman, M.D., Assistant Research Physician in the Immune Deficiency Cellular Therapy Program, is researching a drug therapy for cGVHD. The trial will take place at the NIH Clinical Center in Bethesda, Maryland, and there is no cost for participation.
Clinicaltrials.gov identifier: NCT05531786
NCI Protocol ID: 000643
Official Title: Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
The Center for Cancer Research is NCI’s internal cancer center, a publicly funded organization working to improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care. Highly trained physician-scientists develop and carry out clinical trials to create the medicines of tomorrow treating patients at the world’s largest dedicated research hospital on the campus of the National Institutes of Health in Bethesda, Maryland.