Adults with advanced adenosquamous carcinoma of the pancreas (ASCP) may be eligible to participate in a new clinical trial at the NIH Clinical Center.
ASCP is a rare type of pancreatic cancer that is particularly aggressive. Christine Campo Alewine, M.D., Ph.D., Lasker Clinical Research Scholar in the Laboratory of Molecular Biology, is conducting a study to see if the drug Minnelide can effectively treat ASCP.
MYC is a family of regulator genes that drive ASCP cell growth. Minnelide works in part by inhibiting MYC. It rapidly releases an antitumor molecule into the bloodstream that slows cancer cell growth and induces cancer cell death. Investigators want to see if Minnelide alone can help to shrink ASCP tumors.
NCI Protocol ID: NCI-00-0-254
Official Title: A Phase II Trial of the Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)
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