Our clinical trials are enrolling patients with recurrent or metastatic head and neck cancer, olfactory neuroblastoma (ONB; also known as esthesioneuroblastoma) and recurrent respiratory papillomatosis (RRP).
All clinical trial-related treatments and tests are provided at no cost, and no insurance is required. All treatments are given at the NIH Clinical Center in Bethesda, MD, the world's largest dedicated research hospital.
Have questions or need help finding a clinical trial? Please call 1-888-624-1937 or submit a patient inquiry application.
Clinical Trials Led by Dr. Charalampos S. Floudas
List available on Dr Floudas' CCR profile
Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
A clinical trial studying enasidenib, the oral inhibitor of mutated IDH2, in patients with sinonasal undifferentiated carcinoma, olfactory neuroblastoma, sinonasal adenocarcinoma, large cell neuroendocrine carcinoma (of sinonasal primary), or chondrosarcoma (of sinonasal primary) whose tumors carry this mutation.
ID: NCT06176989
Principal Investigator: Charalampos S. Floudas, MD, DMSc, MS
Status: Open - Recruiting
Contact: Reed, Michele, R.N., 240-686-9543
Phase II Trial of Immunotherapeutic HPV vaccine PRGN-2009 with Pembrolizumab before Standard Treatment in Subjects with Newly Diagnosed HPV-Associated Oropharyngeal Cancer
A clinical trial studying the combination of an immunotherapeutic anti-HPV vaccine with a standard immunotherapy drug for patients with p16+ cancer of the tonsil of back of the tongue (HPV-associated oropharynx cancer) that have been newly diagnosed and are preparing for surgery or radiation therapy.
ID: NCT05996523
Principal Investigator: Charalampos S. Floudas, MD, DMSc, MS
Status: Open - Recruiting
Contact: Marissa B. Mallek, R.N., 240-760-7498
Phase 1 with Expansion Cohorts in a Study of NEO-201 In Adults with Chemo-resistant Solid Tumors
A clinical trial studying a combination drug therapy for patients with non-small cell lung cancer, head and neck squamous cell carcinoma, cervical cancers or uterine cancers.
ID: NCT03476681
Principal Investigator: Kevin Conlon, MD
Status: Open - Recruiting
Contact: Irene Ekwede, 240-760-6126
A Natural History Study of Children and Adults With Olfactory Neuroblastoma
A clinical trial observing symptoms and health problems of people with olfactory neuroblastoma to better understand the disease and find better treatment.
ID: NCT4755205
Status: Open - Recruiting
Contact: Marissa B. Mallek, R.N., 240-760-7498
Clinical Trials Led by Dr. Scott M. Norberg
List available on Dr Norberg's CCR profile
A Phase II Study of Bevacizumab in Adults with Recurrent Respiratory Papillomatosis (RRP)
A clinical trial analyzing a drug therapy for patients with recurrent respiratory papillomatosis disease.
ID: NCT05797246
Status: Open - Recruiting
Contact: Melissa Wheatley, 240-858-3391
Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis
A clinical trial analyzing a drug therapy for patients with recurrent respiratory papillomatosis disease.
ID: NCT04724980
Status: Open - Recruiting
Contact: Erin Ferraro, 240-760-6163
E7 TCR T Cells for Human Papillomavirus-Associated Cancers
A clinical trial analyzing T-cell therapy for HPV-associated cancers.
ID: NCT02858310
Status: Open - Recruiting
Contact: Erin Ferraro, 240-760-6163
T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers
A clinical trial analyzing T-cell receptor gene therapy for cancers that express KK-LC-1, a cancer germline antigen.
ID: NCT05035407
Status: Open - Recruiting
Contact: Erin Ferraro, 240-760-6163
Clinical Trial Led by Dr. Jason M. Redman
List available on Dr Redman's CCR profile
Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer
A clinical trial studying a combination immunotherapy and drug therapy for patients with gastric or head and neck cancer.
ID: NCT04847466
Status: Open - Recruiting
Contact: NCI Medial Oncology Referral Office, 240-760-6050
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
A clinical trial studying a new combination drug therapy for metastatic HPV-associated cancers.
ID: NCT04708470
Status: Open - Recruiting
Contact: Deneise Francis, 240-858-3974
Clinical Trials Led by Dr. Vassiliki Saloura
List available on Dr Saloura's CCR profile
Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
A clinical trial studying the side effects of chemotherapy for patients with locally recurrent head and neck squamous cell carcinoma.
ID: NCT03803774
Status: Open - Recruiting
Contact: Elizabeth Akoth, 240-858-3154
Phase 2, Open-label, Single-arm, Window of Opportunity Study of ASP-1929 Photoimmunotherapy with Fluorescence Imaging in Patients With Operable Primary or Recurrent Head and Neck or Cutaneous Squamous Cell Carcinoma
A clinical trial for patients with head and neck cancer or cutaneous squamous cell carcinoma.
ID: NCT05182866
Status: Open - Recruiting
Contact: NCI Medial Oncology Referral Office, 240-760-6050
A Phase Ib/II Multicenter Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: the PANTHERAS
A clinical trial studying a combination immunotherapy for patients with head and neck cancer.
ID: NCT05879484
Status: Open - Not yet Recruiting
Contact: NCI Medial Oncology Referral Office, 240-760-6050
Have questions or need help finding a clinical trial? Please call 1-888-624-1937 or submit a patient inquiry application.