Giovanna  Tosato, M.D.
Giovanna Tosato, M.D.
Senior Investigator
Section Head
Clinical Investigator

Center for Cancer Research
National Cancer Institute

Building 37, Room 4124
Bethesda, MD 20892-1906
301-594-9596

Our research is focused on the endothelium as a component of the tumor microenvironment, which regulates tumor progression, as source of hematopoietic cells during development, and as component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells.

Areas of Expertise
1) Viral-induced malignancies; EBV and KSHV 2) Angiogenesis; molecular mechanisms and functional interactions 3) Hematopoiesis; endothelium and hematopoietic functional interactions 4) Tumor microenvironment; regulation of tumor progression 5) Immunodeficiency with viral-induced malignancies

The laboratory focuses on the study of the endothelium in the context of cancer development and progression. We study new vessel formation (angiogenesis) and vessel survival as these processes are essential for tumor growth. We investigate the endothelium as a component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis, as hematopoietic cell populations regulate tumor development and progression. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells contributing to tumor development.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Clinical Research, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry
Selected Key Publications
  1. Tosato G, Magrath IT, Koski I, Dooley N, and Blaese RM.
    N. Engl. J. Med. 301: 1133-1137, 1979. [ Journal Article ]
  2. Tosato G, Seamon KB, Goldman ND, Sehgal PB, May LT, Washington GC, Jones KD, and Pike SE.
    Science. 239: 502-504, 1988. [ Journal Article ]
  3. Nakayama T, Mutsuga N, and Tosato G.
    J. Natl. Cancer Inst. 99: 223-235, 2007. [ Journal Article ]
  4. Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, and Tosato G.
    Blood. 120: 4104-4115, 2012. [ Journal Article ]
  5. EphrinB2 controls vessel pruning via STAT1 and JNK3 signaling.
    Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon SO, Segarra M, Eberhart CG, Acker-Palmer A, and Tosato G.
    Nat. Commun. In press: 2015. [ Journal Article ]

Dr. Tosato attended the La Sapienza Medical School in Rome, Italy, where she received her M.D. in 1973 and completed her residency in medicine at the Catholic University in Rome. In 1976, she came to the NCI where she became a Clinical Associate in the Pediatric and Medicine Branches and subsequently a visiting fellow in the Metabolism Branch. In 1983, Dr. Tosato began working at the Food and Drug Administration. From 1992-99 she served as Director, Division of Hematologic Products, Center for Biologics Evaluation and Research, FDA. In 1999 Dr. Tosato returned to the NCI as a senior investigator.

Name Position
Inn-Inn Chen Special Volunteer
Michael Diprima Postbaccalaureate Fellow
Ciara Egan Special Volunteer
Georgina Espigolfrigole Special Volunteer
Hyeong Kwak Ph.D. Postdoctoral Fellow (Visiting)
Arianna Maciejewski Ph.D. Special Volunteer
Nicole Mills Special Volunteer
Hidetaka Ohnuki Postdoctoral Fellow (Visiting)
Ombretta Salvucci Ph.D. Staff Scientist
David Sanchez Martin Ph.D. Postdoctoral Fellow (Visiting)

Summary

Our research is focused on the endothelium as a component of the tumor microenvironment, which regulates tumor progression, as source of hematopoietic cells during development, and as component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells.

Areas of Expertise
1) Viral-induced malignancies; EBV and KSHV 2) Angiogenesis; molecular mechanisms and functional interactions 3) Hematopoiesis; endothelium and hematopoietic functional interactions 4) Tumor microenvironment; regulation of tumor progression 5) Immunodeficiency with viral-induced malignancies

Research

The laboratory focuses on the study of the endothelium in the context of cancer development and progression. We study new vessel formation (angiogenesis) and vessel survival as these processes are essential for tumor growth. We investigate the endothelium as a component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis, as hematopoietic cell populations regulate tumor development and progression. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells contributing to tumor development.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Clinical Research, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry

Publications

Selected Key Publications
  1. Tosato G, Magrath IT, Koski I, Dooley N, and Blaese RM.
    N. Engl. J. Med. 301: 1133-1137, 1979. [ Journal Article ]
  2. Tosato G, Seamon KB, Goldman ND, Sehgal PB, May LT, Washington GC, Jones KD, and Pike SE.
    Science. 239: 502-504, 1988. [ Journal Article ]
  3. Nakayama T, Mutsuga N, and Tosato G.
    J. Natl. Cancer Inst. 99: 223-235, 2007. [ Journal Article ]
  4. Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, and Tosato G.
    Blood. 120: 4104-4115, 2012. [ Journal Article ]
  5. EphrinB2 controls vessel pruning via STAT1 and JNK3 signaling.
    Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon SO, Segarra M, Eberhart CG, Acker-Palmer A, and Tosato G.
    Nat. Commun. In press: 2015. [ Journal Article ]

Biography

Dr. Tosato attended the La Sapienza Medical School in Rome, Italy, where she received her M.D. in 1973 and completed her residency in medicine at the Catholic University in Rome. In 1976, she came to the NCI where she became a Clinical Associate in the Pediatric and Medicine Branches and subsequently a visiting fellow in the Metabolism Branch. In 1983, Dr. Tosato began working at the Food and Drug Administration. From 1992-99 she served as Director, Division of Hematologic Products, Center for Biologics Evaluation and Research, FDA. In 1999 Dr. Tosato returned to the NCI as a senior investigator.

Team

Name Position
Inn-Inn Chen Special Volunteer
Michael Diprima Postbaccalaureate Fellow
Ciara Egan Special Volunteer
Georgina Espigolfrigole Special Volunteer
Hyeong Kwak Ph.D. Postdoctoral Fellow (Visiting)
Arianna Maciejewski Ph.D. Special Volunteer
Nicole Mills Special Volunteer
Hidetaka Ohnuki Postdoctoral Fellow (Visiting)
Ombretta Salvucci Ph.D. Staff Scientist
David Sanchez Martin Ph.D. Postdoctoral Fellow (Visiting)