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Brad Wood, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 1C341
- Bethesda, MD 20892
- 301-443-8191
- bwood@nih.gov
RESEARCH SUMMARY
Dr. Bradford Wood directs a multi-disciplinary team at the NIH Center for Interventional Oncology that develops and translates devices, software and navigation approaches for cancer patients via novel local and regional minimally-invasive image-guided therapies.
At CCR, Dr. Wood serves as an adjunct investigator in the Urologic Oncology Branch's clinical core and is also a member of the NCI CCR Liver Cancer Program.
Areas of Expertise
Information for Patients
Learn more about our clinical trials and the highly specialized care teams that lead them.
Research
Dr. Wood is Chief of IR and founding Director of the NIH Center for Interventional Oncology that develops and translates novel devices, software, and navigation approaches for cancer patients within a multi-disciplinary framework. Biomedical engineering is applied to unmet clinical needs via novel local and regional minimally-invasive image-guided therapies. His team's achievements include helping to pioneer technologies from concept to bench to patient, including “first-in-human” for the following:
kidney, adrenal and pheochromocytoma cancer ablation; prostate cancer MRI/TRUS fusion biopsy and ablation; image-able iodinated drug eluting beads for chemoembolization; heat-deployed nanoparticle chemotherapy with thermal ablation for cancer; electromagnetic tracking for fusion of ultrasound to CT, MR, and PET; and fusion for biopsy and ablation. The NCI CCR liver cancer team (with CCR's Tim Greten) was also the first in clinical trials to combine check point immunotherapies with local and regional image-guided thermal ablation or chemo-embolization for liver and biliary tract cancers.
Metrics include > 50 patents, books on Radiology & Interventional Urology, > 600 publications (H-index of 112) including JAMA, NEJM, Nature Medicine, Nature Comm, Science, Lancet, Cancer, Science Transl Med, JNCI, JAMA Oncology, Hepatology, & Medical Physics. The team's research relies upon multi-disciplinary international public-private partnerships, and the team has mentored hundreds of students, fellows, physicians, nurses, and scientists.
Teamwork and team science breed success.
Publications
Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer
First Human Experience with Directly Image-able Iodinated Embolization Microbeads
Combined locoregional-immunotherapy for liver cancer
In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer
Biography
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Brad Wood, M.D.
Dr. Wood earned undergraduate & graduate degrees from the University of Virginia, internship in internal medicine, & residency at Georgetown University in Radiology and IR. He was on staff at Massachusetts General Hospital at Harvard after fellowships there in Abdominal Imaging and Intervention & Vascular & Interventional Radiology. He is a Fellow of the Society of Interventional Radiology and was Acting Co-Director of Radiology in the late 2000’s. He holds appointments in the NIH Clinical Center, the National Cancer Institute, Urological Oncology Branch, and as Acting Clinical Director of the NIBIB Center for Biomedical Engineering Technology Acceleration. He has received the NIH Director's Awards, NIH Clinical Center Director's Awards, NIH CC CEO Awards, NIH Bench to Bedside Awards, NIH OD Honor Award, NCI Research Highlights Award, and has co-authored > 650 peer-reviewed papers (H-Index = 112), > 50 patents, and several books. He was the primary inventor of fusion biopsy and fusion ablation. First in human successes include RFA for kidney cancer, pheochromocytoma, & adrenal cancer; fusion biopsy & ablation for cancer; image-able drug-eluting beads for TACE; & ablation or embolization plus checkpoint inhibition for immunomodulation in HCC (with Tim Greten). His success is on the shoulders of a stellar, diverse, and fun multi-disciplinary team.
Team
News
NIH Clinical trials using commercialized NIH fusion biopsy inventions are reported in JAMA and New England Journal of Medicine demonstrating improved prostate cancer diagnosis, characterization and triage.
https://www.sharecare.com/cancer/cancer-prevention/cancer-treatment-technology
https://clinicalcenter.nih.gov/centerio/index.html