Marielle E. Yohe, M.D., Ph.D.
Dr. Yohe is a physician scientist with a research focus on understanding how molecular signaling events contribute to epigenetic changes that ultimately result in the development and metastasis of pediatric cancers. Specifically, Dr. Yohe is actively engaged in translational research aimed at targeting signaling pathways downstream of small GTPases, such as RAS, in rhabdomyosarcoma and neuroblastoma.
More than 30% of all human malignancies are driven by mutant RAS isoforms. In addition to well characterized roles in malignant transformation and tumor progression, oncogenic RAS is also able to block differentiation within a cancer cell. We have previously shown that inhibiting the RAS-RAF-MEK-ERK MAP kinase pathway restores the differentiation of rhabdomyosarcoma cells by affecting the transcription of the master transcription factor, MYOG. Current laboratory projects include characterizing the effect of oncogenic RAS on the differentiation of neuroblastoma cells and identifying mechanisms by which rhabdomyosarcoma cells acquire resistance to MAP kinase pathway inhibitors. In addition, the laboratory is engaged in translational research aimed at identifying additional RAS-directed therapeutics for pediatric cancers.
Selected Key Publications
- Cancer Discovery. 7: 884-899, 2017. [ Journal Article ]
- Critical Reviews in Oncogenesis. 20: 227-243, 2015. [ Journal Article ]
- PLoS Genetics. 11: e1005075, 2015. [ Journal Article ]
Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.Biochemistry. 47: 6827-39, 2008. [ Journal Article ]
- Journal of Biological Chemistry. 2007: 13813-23, 2007. [ Journal Article ]
After completing her undergraduate work at Wellesley College, Dr. Yohe received her M.D. and Ph.D from the University of North Carolina at Chapel Hill. She did her graduate work in the laboratory of Dr. John Sondek in the Department of Pharmacology. In this work, she addressed how truncation of Dbl-family Rho guanine nucleotide exchange factors leads to their aberrant activation. She completed her internship and residency in pediatrics at Connecticut Children's Medical Center in Hartford, CT, followed by fellowship training at the combined National Cancer Institute - Johns Hopkins University Hematology/Oncology program. She did her postdoctoral work in the laboratory of Dr. Javed Khan in the Genetics Branch of the CCR.
Dr. Yohe is board certified in General Pediatrics (2013) and Pediatric Hematology/Oncology (2017). She is the recipient of an Alex's Lemonade Stand Foundation Young Investigator Award.
|Joshua Kowalczyk B.S.||Postbaccalaureate Fellow (CRTA)|