Tatiana S. Karpova, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 41, Room C615
- Bethesda, MD 20892
- 240-760-6637
- karpovat@mail.nih.gov
RESEARCH SUMMARY
Dr. Karpova manages the NCI Optical Microscopy Core. This facility specializes in live imaging, image deconvolution and microscopy quantification methods such as FRET and FRAP. Dr. Karpova conducts research focusing on the regulation of gene expression by chromatin remodelers by observing protein interaction in vivo in live yeast cells. Her research interests include: -the intracellular dynamics of chromatin remodelers, transcriptional activators and co-activators; and -the role of nuclear localization on gene expression as observed in live yeast cells by microscopy.
Areas of Expertise
Research
Dr. Karpova manages the NCI Optical Microscopy Core. This facility specializes in live imaging, image deconvolution and microscopy quantification methods such as FRET and FRAP. Dr. Karpova conducts research focusing on the regulation of gene expression by chromatin remodelers by observing protein interaction in vivo in live yeast cells. Her research interests include: -the intracellular dynamics of chromatin remodelers, transcriptional activators and co-activators; and -the role of nuclear localization on gene expression as observed in live yeast cells by microscopy.
Publications
- Bibliography Link
- View Dr. Karpova's Complete Bibliography at ORCID
Dynamic interactions of a transcription factor with DNA are accelerated by a chromatin remodeler
Concurrent fast and slow cycling of a transcriptional activator at an endogenous promoter
Measuring chromatin interaction dynamics on the second time scale at single-copy genes
Single Molecule Tracking Of Ace1p In Saccharomyces cerevisiae Defines A Characteristic Residence Time For Non-specific Interactions Of Transcription Factors With Chromatin
Single-Molecule analysis reveals linked cycles of RSC chromatin remodeling and Ace1p transcription factor binding in yeast
Biography
Tatiana S. Karpova, Ph.D.
Tatiana Karpova obtained her Ph.D. in genetics from St. Petersburg State University (Leningrad, Russia) in 1984. From 1984-1991 she worked as an instructor and then as a senior lecturer in the Department of Genetics at St. Petersburg State University and conducted research in the field of genetic control of translation and translation termination factors in yeast. In 1991 Dr. Karpova was awarded the FEBS fellowship for research at Vrije University (Amsterdam, Holland). From 1992-1999 Dr. Karpova was a postdoctoral fellow in the Department of Cell Biology and Physiology, Washington University School of Medicine (St. Louis, MO). Her research involved genetics and microscopy of actin cytoskeleton in yeast. Dr. Karpova was one of the first scientists able to observe the actin cytoskeleton using green fluorescent protein (GFP) fusion protein markers in live yeast. In 1993-1995 she was awarded an American Heart Association Fellowship. From 1999 to date, Dr. Karpova has managed the NCI Optical Microscopy Core.
