Tatiana S. Karpova, Ph.D.

Tatiana S. Karpova, Ph.D.
Facility Head
Head, NCI Optical Microscopy Core

Dr. Karpova manages the NCI Optical Microscopy Core. This facility specializes in live imaging, image deconvolution and microscopy quantification methods such as FRET and FRAP. Dr. Karpova conducts research focusing on the regulation of gene expression by chromatin remodelers by observing protein interaction in vivo in live yeast cells. Her research interests include: -the intracellular dynamics of chromatin remodelers, transcriptional activators and co-activators; and -the role of nuclear localization on gene expression as observed in live yeast cells by microscopy.

Areas of Expertise
Fluorescence Imaging

Contact Info

Tatiana S. Karpova, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room C615
Bethesda, MD 20892
Ph: 240-760-6637
karpovat@mail.nih.gov

Dr. Karpova manages the NCI Optical Microscopy Core. This facility specializes in live imaging, image deconvolution and microscopy quantification methods such as FRET and FRAP. Dr. Karpova conducts research focusing on the regulation of gene expression by chromatin remodelers by observing protein interaction in vivo in live yeast cells. Her research interests include: -the intracellular dynamics of chromatin remodelers, transcriptional activators and co-activators; and -the role of nuclear localization on gene expression as observed in live yeast cells by microscopy.

  1. Karpova TS, Chen TY, Sprague BL, McNally JG.
    EMBO Rep.. 5: 1064-1070, 2004. [ Journal Article ]
  2. Karpova TS, Kim MJ, Spriet C, Nalley K, Stasevich TJ, Kherrouche Z, Heliot L, McNally JG.
    Science. 319: 466-469, 2008. [ Journal Article ]
  3. Poorey K, Viswanathan R, Carver MN, Karpova TS, Cirimotich SM, McNally JG, Bekiranov S, Auble DT.
    Science. 342: 369-72, 2013. [ Journal Article ]
  4. Ball DA, Mehta GD, Salomon-Kent,R., Mazza D, Morisaki T, Mueller F, McNally JG, Karpova TS
    Nucleic Acids Res. 44: e160, 2016. [ Journal Article ]
  5. Mehta GD, Ball DA, Eriksson PR, Chereji RV, Clark DJ, McNally JG, Karpova TS
    Molecular Cell. 72: 875-887, 2018. [ Journal Article ]

Tatiana Karpova obtained her Ph.D. in genetics from St. Petersburg State University (Leningrad, Russia) in 1984. From 1984-1991 she worked as an instructor and then as a senior lecturer in the Department of Genetics at St. Petersburg State University and conducted research in the field of genetic control of translation and translation termination factors in yeast. In 1991 Dr. Karpova was awarded the FEBS fellowship for research at Vrije University (Amsterdam, Holland). From 1992-1999 Dr. Karpova was a postdoctoral fellow in the Department of Cell Biology and Physiology, Washington University School of Medicine (St. Louis, MO). Her research involved genetics and microscopy of actin cytoskeleton in yeast. Dr. Karpova was one of the first scientists able to observe the actin cytoskeleton using green fluorescent protein (GFP) fusion protein markers in live yeast. In 1993-1995 she was awarded an American Heart Association Fellowship. From 1999 to date, Dr. Karpova has managed the NCI Optical Microscopy Core.

Name Position
David A. Ball, Ph.D. Staff Scientist
Gunjan Mehta Ph.D. Postdoctoral Fellow (Visiting)