Markku Martti Miettinen, M.D., Ph.D.

Markku Martti Miettinen, M.D., Ph.D.
Senior Clinician
Laboratory of Pathology
Head, General Surgical Pathology Section

The mission of Division of the Surgical Pathology is to provide the most accurate and timely pathology consultations serving the clinical trials of the NCI/NIH using the latest technology integrated in morphologic evaluation. Dr. Miettinen's research interests include pathology of soft tissue tumors and gastrointestinal stromal tumor (GIST). His group has delineated the prognostication system for GIST and clinicopathologic profile or GISTs of different sites. Current work includes prognostic, molecular, and biomarker analysis of sporadic and syndromic GISTs and evaluation of new diagnostic markers for soft tissue sarcomas and related tumors.

Areas of Expertise

1) gastrointestinal stromal tumor (GIST), 2) soft tissue sarcoma

Contact Info

Markku Martti Miettinen, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 2S235C
Bethesda, MD 20892
Ph: 301-480-8947
miettinenmm@mail.nih.gov

The mission of Division of the Surgical Pathology is to provide the most accurate and timely pathology consultations serving the clinical trials of the NCI/NIH using the latest technology integrated in morphologic evaluation. Dr. Miettinen's research interests include pathology of soft tissue tumors and gastrointestinal stromal tumor. His group has delineated the prognostication system for GIST and clinicopathologic profile or GISTs of different sites. Current work includes prognostic, molecular, and biomarker analysis of sporadic and syndromic GISTs and evaluation of new diagnostic markers for soft tissue sarcomas and related tumors.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research
View Dr. Miettinen's PubMed Summary.

Selected Recent Publications

  1. Anaplastic Lymphoma Kinase Gene Rearrangement in Children and Young Adults With Mesothelioma.
    Mian I, Abdullaev Z, Morrow B, Kaplan RN, Gao S, Miettinen M, Schrump DS, Zgonc V, Wei JS, Khan J, Pack S, Hassan R.
    J Thorac Oncol. 15(3): 457-61, 2020. [ Journal Article ]
  2. A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.
    Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC.
    Clin Cancer Res. 25(21): 6302-8, 2019. [ Journal Article ]
  3. Primary malignant melanoma of esophagus: clinicopathologic characterization of 20 cases including molecular genetic profiling of 15 tumors.
    Lasota J, Kowalik A, Felisiak-Golabek A, Zięba S, Waloszczyk P, Masiuk M, Wejman J, Szumilo J, Miettinen M.
    Mod Pathol. 32(7): 957-66, 2019. [ Journal Article ]
  4. ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.
    Shukla V, Rao M, Zhang H, Beers J, Wangsa D, Wangsa D, Buishand FO, Wang Y, Yu Z, Stevenson HS, Reardon ES, McLoughlin KC, Kaufman AS, Payabyab EC, Hong JA, Zhang M, Davis S, Edelman D, Chen G, Miettinen MM, Restifo NP, Ried T, Meltzer PA, Schrump DS.
    Cancer Res. 77(22): 6267-81, 2017. [ Journal Article ]
  5. Myxoinflammatory fibroblastic sarcoma: a clinicopathologic analysis of 104 cases, with emphasis on predictors of outcome.
    Laskin WB, Fetsch JF, Miettinen M.
    Am. J. Surg. Pathol. 38: 41651, 2014. [ Journal Article ]

Dr. Miettinen earned the degrees of M.D. in 1977 and Ph.D. in 1983 from the University of Helsinki Medical School, where he also completed his residency in anatomic pathology in 1982. Previously, he served as a Chairman and Registrar and Distinguished Scientist of the Department of Soft Tissue and Orthopedic Pathology in the Armed Forces Institute of Pathology for 15 years and Professor of Pathology and attending pathologist at the Jefferson Medical College and Thomas Jefferson University Hospital. He was also an attending pathologist and assistant professor of pathology at the University of Helsinki and its affiliated hospitals. He serves on the editorial boards of American Journal of Surgical Pathology, Human Pathology, The Journal of Pathology, and Applied Immunohistochemistry and Molecular Morphology.

Name Position
Anna Felisiak-Golabek Ph.D. Postdoctoral Fellow (Visiting)
Cynthia Harris Medical Technologist
Hong Jin Medical Technologist
Jerzy P. Lasota Ph.D. Staff Scientist
Chyi-Chia Richard Lee, M.D., Ph.D. Staff Clinician
Ralph Nix Patient Care Coordinator
Martha M. Quezado M.D. Staff Clinician
Charisma Roque Medical Technologist