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Sergio Ruiz Macias, Ph.D.

Sergio Ruiz Macias, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity

RESEARCH SUMMARY

I have always been amazed by how a single cell can originate a whole organism. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are my scientific interests.

Areas of Expertise

Embryonic Stem Cells
Pluripotency
Somatic Cell Reprogramming
CRISPR-Based Screenings
Differentiation

Publications

Selected Recent Publications

CTCF is a barrier for 2C-like reprogramming

Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S
Nat. Commun. 12(1):4856: 2021.
Full-Text Article
[ Journal Article ]

The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner

Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S
Sci. Adv. 7(40):eabg8306: 2021.
Full-Text Article
[ Journal Article ]

ERF deletion rescues RAS deficiency in mouse embryonic stem cells

Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, and Fernández-Capetillo O.
Genes Dev. 32(7-8): 568-76, 2018.
Full-Text Article
[ Journal Article ]

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gómez C, Ortega S, Ruiz S, and Fernández-Capetillo O.
Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.
Full-Text Article
[ Journal Article ]

A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors

Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, and Fernández-Capetillo O.
Mol Cell. 62: 307-13, 2016.
Full-Text Article
[ Journal Article ]

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Team

Bechara Saykali
Postdoctoral Fellow (Visiting)
Bechara Saykali, Ph.D.
Maria Vega Sendino
POSTDOCTORAL FELLOW (VISITING)
Maria Vega Sendino, Ph.D.
Sarah
POSTDOCTORAL FELLOW (CRTA)
Sarah C. Hoelscher, Ph.D.
POSTBACCALAUREATE FELLOW
Bhavya Soni, B.S.

News

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