Giovanna Tosato, M.D.
Our research is focused on the endothelium as a component of the tumor microenvironment, which regulates tumor progression, as source of hematopoietic cells during development, and as component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells.
1) viral-induced malignancies; EBV and KSHV, 2) angiogenesis; molecular mechanisms and functional interactions, 3) hematopoiesis; endothelium and hematopoietic functional interactions, 4) tumor microenvironment; regulation of tumor progression,
5) immunodeficiency with viral-induced malignancies
The laboratory focuses on the study of the endothelium in the context of cancer development and progression. We study new vessel formation (angiogenesis) and vessel survival as these processes are essential for tumor growth. We investigate the endothelium as a component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis, as hematopoietic cell populations regulate tumor development and progression. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells contributing to tumor development.
Selected Recent Publications
- Nat. Commun. 6: 6576, 2015. [ Journal Article ]
Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling.Science Signaling. 9(419): ra28, 2016. [ Journal Article ]
Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow.J. Clin. Invest. 126(12): 4554-68, 2016. [ Journal Article ]
- Journal of the National Cancer Institute. 2017 Sep 1: 109(9). doi: 10.1093/jnci/djx016, 2017. [ Journal Article ]
Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression.J Natl Cancer Inst.. 2018 Apr 1: 110(4):390-399. doi: 10.1093/jnci/djx219, 2018. [ Journal Article ]
Dr. Tosato attended the La Sapienza Medical School in Rome, Italy, where she received her M.D. in 1973 and completed her residency in medicine at the Catholic University in Rome. In 1976, she came to the NCI where she became a Clinical Associate in the Pediatric and Medicine Branches and subsequently a visiting fellow in the Metabolism Branch. In 1983, Dr. Tosato began working at the Food and Drug Administration. From 1992-99 she served as Director, Division of Hematologic Products, Center for Biologics Evaluation and Research, FDA. In 1999 Dr. Tosato returned to the NCI as a senior investigator.
|Michael Diprima Ph.D.||Postdoctoral Fellow (CRTA)|
|Jingxin Feng Ph.D.||Postdoctoral Fellow (Visiting)|
|Taekyu Ha Ph.D.||Research Fellow|
|Hidetaka Ohnuki Ph.D.||Staff Scientist|
|Yuyi Wang Ph.D.||Postdoctoral Fellow (Visiting)|