Christophe Cataisson, Ph.D.
Dr. Cataisson’s research expertise is centered on skin carcinogenesis (cutaneous squamous cell carcinoma) following two-stage chemical carcinogenesis (DMBA-TPA). He also uses primary mouse keratinocytes to define phenotypic changes caused by oncogenic RAS. He uses genetically modified mouse models to study pathways contributing to carcinogenesis (PKC, MyD88, CXCR2, EGFR, MET, MTOR). Using an in vivo grafting model on a syngeneic host has allowed Dr. Cataisson to probe the respective contribution of cancer cells and their stroma to tumor formation.
Dr. Cataisson’s integrated research takes advantage of using primary cells transformed by a single hit (oncogenic RAS) and exploring their phenotype in vivo in a relevant context.
Dr. Cataisson's research expertise is centered on two interrelated areas. He uses mouse models to define pathways contributing to skin inflammation with special emphasis on the chemokine family binding CXCR2. In other studies, he is investigating the role of inflammation in the tumor microenvironment using epidermal squamous carcinoma as a model.
Selected Key Publications
- Sci Signal.. 9(433):ra62: 2016. [ Journal Article ]
- J Exp Med. 209: 1689-702, 2012. [ Journal Article ]
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.Cancer Res. 69: 319-28, 2009. [ Journal Article ]
- J Clin Invest. 116: 2757-66, 2006. [ Journal Article ]
Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo.J Immunol. 174: 1686-92, 2005. [ Journal Article ]
Dr. Christophe Cataisson received an M.S. diploma in cellular biology and physiology from the University Blaise Pascal, Clermont-Ferrand, France, in 1995. He then moved to the University of Jussieu, Paris, France, where he received his Ph.D. in December 2000 for his work on the regulation and function of the Parathyroid Hormone related Peptide (PTHrP) gene in human mammary cancer cells. In 2001, he joined the laboratory of Dr. Stuart Yuspa as a visiting fellow to receive his postdoctoral training.