Christophe Cataisson, Ph.D.

Christophe Cataisson, Ph.D.
Staff Scientist

Team Member of:

Dr. Cataisson’s research expertise is centered on skin carcinogenesis (cutaneous squamous cell carcinoma) following two-stage chemical carcinogenesis (DMBA-TPA). He also uses primary mouse keratinocytes to define phenotypic changes caused by oncogenic RAS. He uses genetically modified mouse models to study pathways contributing to carcinogenesis (PKC, MyD88, CXCR2, EGFR, MET, MTOR). Using an in vivo grafting model on a syngeneic host has allowed Dr. Cataisson to probe the respective contribution of cancer cells and their stroma to tumor formation. 

Dr. Cataisson’s integrated research takes advantage of using primary cells transformed by a single hit (oncogenic RAS) and exploring their phenotype in vivo in a relevant context.

Areas of Expertise

1) skin carcinogenesis, 2) RAS oncogenes, 3) primary keratinocytes, 4) skin inflammation, 5) MyD88, 6) PKC, 7) IL-17, 8) ADAM17

Contact Info

Christophe Cataisson, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 4060
Bethesda, MD 20892
Ph: 240-760-6793

Dr. Cataisson's research expertise is centered on two interrelated areas. He uses mouse models to define pathways contributing to skin inflammation with special emphasis on the chemokine family binding CXCR2. In other studies, he is investigating the role of inflammation in the tumor microenvironment using epidermal squamous carcinoma as a model.

NIH Scientific Focus Areas:
Cancer Biology

Selected Key Publications

  1. Cataisson C, Michalowski AM, Shibuya K, Ryscavage A, Klosterman M, Wright L, Dubois W, Liu F, Zhuang A, Rodrigues KB, Hoover S, Dwyer J, Simpson MR, Merlino G, Yuspa SH
    Sci Signal.. 9(433):ra62: 2016. [ Journal Article ]
  2. Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
    J Exp Med. 209: 1689-702, 2012. [ Journal Article ]
  3. Cataisson C, Ohman R, Patel G, Pearson A, Tsien M, Jay S, Wright L, Hennings H, Yuspa SH.
    Cancer Res. 69: 319-28, 2009. [ Journal Article ]
  4. Cataisson C, Pearson AJ, Tsien MZ, Mascia F, Gao JL, Pastore S, Yuspa SH.
    J Clin Invest. 116: 2757-66, 2006. [ Journal Article ]
  5. Cataisson C, Pearson AJ, Torgerson S, Nedospasov SA, Yuspa SH.
    J Immunol. 174: 1686-92, 2005. [ Journal Article ]

Dr. Christophe Cataisson received an M.S. diploma in cellular biology and physiology from the University Blaise Pascal, Clermont-Ferrand, France, in 1995. He then moved to the University of Jussieu, Paris, France, where he received his Ph.D. in December 2000 for his work on the regulation and function of the Parathyroid Hormone related Peptide (PTHrP) gene in human mammary cancer cells. In 2001, he joined the laboratory of Dr. Stuart Yuspa as a visiting fellow to receive his postdoctoral training.