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Beverly  Mock, Ph.D.

Beverly Mock, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Head, Cancer Genetics Section
CCR Deputy Director

RESEARCH SUMMARY

Dr. Mock’s genome-wide linkage studies have demonstrated that plasmacytomagenesis is a complex trait, with p16, mTOR and Mndal identified as potential plasmacytoma susceptibility genes. Mouse models of common and rare allelic variants of these genes are being utilized to study their functional differences and identify their roles in tumorigenesis. Combinations of pharmacological inhibitors of these pathways are being evaluated for their synergy in limiting tumor cell growth, and the mechanisms underlying this synergy.

Areas of Expertise

Mouse Genetics
B Cell Neoplasia
Systems Pharmacology
Tumor Suppressors

Publications

Selected Recent Publications

Large-Scale Human Myeloma Cell Line Small Molecule Compound Screen Dataset

Hughitt VK, Simmons JK, Gorjifard S, Michalowski A, Wilson K, Zhang X, Shinn P, Klumpp-Thomas C, McKnight C, Itkin Z, Chen L, Michael S, Keats J, Thomas C, Mock BA.
Scientific Data. 12(1): 661, 2025.
Full-Text Article
[ Journal Article ]

Drug Combinations Identified by High-Throughput Screening Promote Cell Cycle Transition and Upregulate Smad Pathways in Myeloma

Peat TJ, Gaikwad SM, Dubois W, Gyabaah-Kessie N, Zhang S, Gorjifard S, Phyo Z, Andres M, Hughitt VK, Simpson RM, Miller MA, Girvin AT, Taylor A, Williams D, D’Antonio N, Zhang Y, Rajagopalan A, Flietner E, Wilson K, Zhang X, Shinn P, Klumpp-Thomas C, McKnight C, Itkin Z, Chen L, Kazandijian D, Zhang J, Michalowski AM, Simmons JK, Keats J, Thomas CJ, Mock BA.
Cancer Letters. 568: 216284, 2023.
Full-Text Article
[ Journal Article ]

Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis

Gary JM, Simmons JK, Xu J, Zhang S, Peat TJ, Watson N, Gamache BJ, Zhang K, Kovalchuk AL, Michalowski AM, Chen J-Q, Thaiwong T, Kiupel M, Gaikwad S, Etienne M, Simpson RM, Dubois W, Testa JR, Mock BA.
Molecular Cancer Therapeutics. 19(10): 2221–2232, 2020.
Full-Text Article
[ Journal Article ]

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

Gaikwad SM, Phyo Z, Arteaga AQ, Gorjifard S, Calabrese DR, Connors D, Huang J, Michalowski AM, Zhang S, Liu Z-G, Schneekloth JS, Mock BA.
Cancers. 12(10): 2952, 2020.
Full-Text Article
[ Journal Article ]

Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy

Eiden AM, Zhang S, Gary JM, Simmons JK, Mock BA.
Clinical Cancer Research. 22(2): 277-83, 2016.
Full-Text Article
[ Journal Article ]

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