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Chongyi Chen, Ph.D.

Chongyi Chen, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

The Chen lab investigates the topological tension of DNA, known as DNA supercoiling, in the context of chromatin organization and gene expression in human cells. By leveraging our expertise in developing novel genomic technologies and single-cell assays, we aim to understand how DNA supercoiling interacts with other chromatin features, shaping the chromatin environment and regulating gene expression. We also study the regulatory mechanisms and functions of DNA supercoiling across various biological and biomedical settings, with a focus on DNA topoisomerase, the primary modulator of DNA supercoiling and a key target in cancer chemotherapy. Our long-term goal is to translate these discoveries in DNA topology and chromatin biology, together with our advanced genomic and single-cell methodologies, into breakthroughs in cancer biology and medicine.

Areas of Expertise

DNA Supercoiling
DNA Topoisomerase
Chromatin Organization
Gene Expression
Genomic Technology and Single-cell Assay Development

Publications

Selected Publications

Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression

Yao Q, Zhu L, Shi Z, Banerjee S, Chen C.
Nature Structural & Molecular Biology. 2024. [ Journal Article ]

A convenient single-cell newly synthesized transcriptome assay reveals gene expression dynamics during early-stage T-cell activation

Lyu J, Xu X, Chen C.
bioRxiv. 2024.
Full-Text Article
[ Journal Article ]

DNA topology: A central dynamic coordinator in chromatin regulation

Li S, Vemuri C, Chen C.
Current Opinion in Structural Biology. 87: 102868, 2024. [ Journal Article ]

Single-cell Whole-genome Analyses by Linear Amplification via Transposon Insertion (LIANTI)

Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, Xie XS.
Science. 356: 189-194, 2017. [ Journal Article ]

Job Vacancies

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Team

Qian Yao
Postdoctoral Fellow (Visiting)
Qian Yao, Ph.D.
Jun Lyu
Postdoctoral Fellow (Visiting)
Jun Lyu, Ph.D.
Linying Zhu
Postdoctoral Fellow (Visiting)
Linying Zhu, Ph.D.
Shuai Li
Post-doctoral Fellow (Visiting)
Shuai Li, Ph.D.
Charan_profile
Postbaccalaureate (CRTA)
Charan Vemuri

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