Kathryn A. Lurain, M.D., M.P.H.
Dr. Lurain is an Assistant Research Physician in the HIV/AIDS Malignancy Branch. She is an expert in the treatment of a variety of HIV-associated cancers, including those caused by the Kaposi sarcoma herpesvirus (KSHV). Her primary research is based in the clinic and is focused on the development of new treatments for primary effusion lymphoma (PEL) and other KSHV-associated diseases. She is an advocate for people living with HIV and their inclusion in clinical trials.
1) primary effusion lymphoma, 2) viral oncology, 3) multicentric Castleman disease,
4) HIV-associated lymphoma, 5) Kaposi sarcoma
Dr. Lurain is a hemato-oncologist within the HIV/AIDS Malignancy Branch. She developed the first prospective clinical trial in primary effusion lymphoma (PEL) combining standard chemotherapy with the immunomodulatory drug, lenalidomide. She has helped elucidate the unique natural history of PEL compared to other HIV-associated lymphomas and identified human interleukins 6 and 10 and the EBV status of the tumor as prognostic markers in this rare disease. Her translational work focuses on understanding the changes in cellular and humoral immune function at the onset of KSHV-associated conditions and how immune function is affected by treatment.
Selected Recent Publications
- Blood. 133(16): 1753-1761, 2019. [ Journal Article ]
- In: Am Soc Clin Oncol Educ Book. 39: 36-40, 2019. [ Book ]
- JAMA Oncol. doi: 10.1001/jamaoncol.2019.2244: [Epub ahead of print], 2019. [ Journal Article ]
- Proc Natl Acad Sci. 115 (50): 12805-12810, 2018. [ Journal Article ]
A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma.Clin Cancer Res. doi: 10.1158/1078-0432.CCR-18-3528: [Epub ahead of print], 2019. [ Journal Article ]
Dr. Lurain earned a Bachelors of Arts in Biology from Oberlin College in 2006 and a Masters in Global Public Health from the George Washington University School of Public Health in 2008. She received her M.D. from the University of Virginia School of Medicine in 2012 and completed her residency in internal medicine at the University of Chicago Medical Center in 2015. In 2018, she completed a fellowship in hematology and oncology at the National Cancer Institute and then joined the HIV/AIDS Malignancy Branch as an Assistant Research Physician. During her fellowship she served as the Chief Fellow during her third year.