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Photograph of Charalampos Floudas

Charalampos “Harris” S. Floudas, MD, DMSc, MS

  • Center for Cancer Research
  • National Cancer Institute
Assistant Research Physician
Center for Immuno-Oncology
Head of HNC Therapy, Immunotherapy Section

RESEARCH SUMMARY

Dr. Floudas is a Head and Neck Cancer (HNC) Medical Oncologist. He is clinically active in drug development for HNC, designing and conducting early-phase immunotherapy clinical trials, addressing Squamous Cell Cancer of the Head and Neck (HNSCC/SCCHN), but also rare cancers, such as Nasopharyngeal Cancer and Olfactory Neuroblastoma (esthesioneuroblastoma). His translational research interests include applying artificial intelligence (AI) and machine learning (ML) to multi-modal omics data for clinical predictive modeling and biomarker discovery, and the exploration of LLM applications in Oncology, particularly in patient-clinical trial matching. 

Areas of Expertise

Cancer Immunology and Immunotherapy
The Tumor Microenvironment
Medical Oncology
Clinical Computational Oncology
Artificial Intelligence/Machine Learning

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Publications

Selected Key Publications

Leveraging mRNA technology for antigen based immuno-oncology therapies

Charalampos S Floudas, Siranush Sarkizova, Michele Ceccarelli, Wei Zheng
Journal for ImmunoTherapy of Cancer (JITC). 13: 2025.
Full-Text Article
[ Journal Article ]

Characterization of Somatostatin Receptor 2 Gene Expression and Immune Landscape in Sinonasal Malignancies

Elisabetta Xue, Dara Bracken-Clarke, Harris Krause, Tolulope Adeyelu, Mark G Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M Vanderwalde, Andrew Elliott, Conor E Steuer, Nabil F Saba, Daniel J Lubin, Nyall R London Jr, James L Gulley, Charalampos S Floudas
Cancers (Basel). 16: 2024.
Full-Text Article
[ Journal Article ]

Matching patients to clinical trials with large language models

Qiao Jin, Zifeng Wang, Charalampos S Floudas, Fangyuan Chen, Changlin Gong, Dara Bracken-Clarke, Elisabetta Xue, Yifan Yang, Jimeng Sun, Zhiyong Lu
Nature Communications. 15(1): 2024.
Full-Text Article
[ Journal Article ]

Comparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study

Giovanni Maria Iannantuono, Dara Bracken-Clarke, Fatima Karzai, Hyoyoung Choo-Wosoba, James L Gulley, Charalampos S Floudas
The Oncologist. 2024.
Full-Text Article
[ Journal Article ]

Real-world pan-cancer landscape of frameshift mutations and their role in predicting responses to immune checkpoint inhibitors in cancers with low tumor mutational burden

Florou V, Floudas CS, Maoz A, Naqash AR, Norton C, Tan AC, Sokol ES, Frampton G, Soares HP, Puri S, Swami U, Wilky B, Hosein P, Trent J, Lopes G de L, Park W, Garrido-Laguna I.
Journal for ImmunoTherapy of Cancer (JITC) . 2023.
Full-Text Article
[ Journal Article ]