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Scott M. Norberg, D.O.

Scott M. Norberg, D.O.

  • Center for Cancer Research
  • National Cancer Institute
Associate Research Physician
Center for Immuno-Oncology
Head, Solid Tumor Cellular Therapy Group

RESEARCH SUMMARY

Dr. Norberg researches the use of immunotherapy and cellular therapy for a variety of conditions including human papillomavirus-positive (HPV+) cancers and premalignant diseases caused by chronic HPV infection. His research focuses on understanding resistance to immunotherapy and cellular therapies and applying these treatment modalities to other conditions. 

Areas of Expertise

Cell Therapy
Immunotherapy
Human Papillomavirus
Cervical Cancer
Oropharyngeal Cancer

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Clinical Trials

Publications

Selected Recent Publications

PRGN-2012 gene therapy in adults with recurrent respiratory papillomatosis: a pivotal phase 1/2 clinical trial

Norberg SM, Valdez J, Napier S, Kenyon M, Ferraro E, Wheatley M, Parsons-Wandell L, Doran SL, Lankford A, Sabzevari H, Brough DE, Schlom J, Gulley JL, Allen CT
Lancet Respir Med. 13(4): 318-326, 2025. [ Journal Article ]

Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants

Zhang L, Norberg SM, Karimipour F, Davies JS, Kuznetsov A, Lassoued W, Burnett D, Homan P, Cam M, Sinkoe A, Xue P, Gulley JL, Hinrichs CS
J Immunother Cancer. 12(11): 2024. [ Journal Article ]

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

Norberg SM, Bai K, Sievers C, Robbins Y, Friedman J, Yang X, Kenyon M, Ward E, Schlom J, Gulley J, Lankford A, Semnani R, Sabzevari H, Brough DE, Allen CT
Sci Transl Med. 15(719): 2023. [ Journal Article ]

Engineered T cell therapy for viral and non-viral epithelial cancers

Norberg SM, Hinrichs CS
Cancer Cell. 41(1): 58-69, 2023. [ Journal Article ]

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanovic S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS.
Nat Med. 2021.
Full-Text Article
[ Journal Article ]