Yoshimi Endo Greer, M.D., Ph.D.

Yoshimi Endo Greer, M.D., Ph.D.
Associate Scientist

Yoshimi E. Greer, MD., Ph.D. is an experienced scientist in cell biology, molecular biology, biochemistry and oncology. Her current research interests are 1) TRAIL-induced cell death, and 2) targeting mitochondria in cancer. She is exploring clinical applications utilizing those approaches in cancer therapeutics, particularly breast cancers.

Areas of Expertise

1) breast cancer, 2) cell death, 3) TRAIL/death receptor, 4) mitochondria,
5) signal transduction

Contact Info

Yoshimi Endo Greer, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building.10, Room4B50
Bethesda, MD 20892-4256
Ph: 240-858-3275
NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry

Selected Publications

  1. Greer YE, Gilbert SF, Gril B, Narwal R, Peacock Brooks DL, Tice DA, Steeg PS, Lipkowitz S.
    Breast Cancer Research. 21(1): 27, 2019. [ Journal Article ]
  2. Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, Tran B, Jailwala P, Cam M, Lang M, Voeller D, Reinhold WC, Rajapakse V, Pommier Y, Weigert R, Linehan WM, Lipkowitz S.
    Oncotarget. 9: 18454-18479, 2018. [ Journal Article ]
  3. Greer YE and Lipkowitz S.
    Science Signaling. 9: 415, 2016. [ Journal Article ]
  4. Dine JL, O'Sullivan CC, Voeller D, Greer YE, Chavez KJ, Conway CM, Sinclair S, Stone B, Amiri-Kordestani L, Merchant AS, Hewitt SM, Steinberg SM, Swain SM, Lipkowitz S.
    Breast Cancer Res Treat. 155(2): 235-51, 2016. [ Journal Article ]
  5. Greer YE, Lipkowitz S.
    Oncoscience. 2(2): 75-6, 2015. [ Journal Article ]

Dr. Yoshimi E. Greer obtained her M.D. in 1994 from Tohoku University School of Medicine, Japan. She conducted clinical residency training in internal medicine for 5 years. In 1999, she received Ph.D. in renal physiology the Graduate School of Tohoku University, Japan. 

In 1998, she joined Dr. Josephine P. Briggs' lab at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as a postdoctoral fellow. In 2001, she transferred to Dr. Jeffrey S. Rubin's lab in NCI, and studied Wnt signaling in cancer. In 2004, she joined Lombardi Comprehensive Cancer Center, Georgetown University Medical School in Washington DC as a research instructor, and studied breast cancer.

In 2006, she returned to NCI as a research fellow, and continued Wnt signaling research in cancer. In 2009, she became a staff scientist in the Laboratory of Cellular and Molecular Biology (LCMB), CCR.

In 2014, she joined Dr. Stan Lipkowitz’s lab to explore her great interest in oncology and translational research in breast cancer. Her current research focuses are 1) to develop breast cancer treatment strategies utilizing TRAIL/Death Receptor, 2) to investigate the role of mitochondria in cancer as a therapeutic target.

In 2021, Dr. Greer is promoted to Associate Scientist.