Samira M. Sadowski, M.D.

Samira M. Sadowski, M.D.
Physician-Scientist Early Investigator
Head, Neuro-endocrine Cancer Therapy Section

Dr. Sadowski’s research focuses on the identification of diagnostic and prognostic markers for endocrine tumors and developing new therapies for such tumors. She has extensive experience in the field of endocrine surgery.

Areas of Expertise

1) thyroid, 2) parathyroid, 3) neuroendocrine tumors of the pancreas and GI tract,
4)  pheochromocytoma / paraganglioma 

Contact Info

Samira M. Sadowski, M.D.
Center for Cancer Research
National Cancer Institute
Building 10 CRC, Room 4-5932
Bethesda, MD 20892
Ph: 240-858-3413

Neuroendocrine tumors are a diverse and increasingly common set of cancers. While some of these tumors are known to have a hereditary component, in general they are understudied and often fatal.

Dr. Sadowski’s work addresses the critical gaps in our knowledge of the basic mechanisms of neuroendocrine tumor biology, such as the high variability in receptor density and treatment response in patients with identical histology and tumor grade or the difficulties in detecting disease. She is seeking to uncover new therapies for neuroendocrine tumors in order to improve patient survival. To this end, she intends to establish a reproducible model for neuroendocrine tumor research and elucidate regulation of the neuroendocrine tumor surface receptor repertoire.

Dr. Sadowski’s translational and clinical investigations have three main goals: 1) to develop effective therapies for rare and neglected endocrine cancers, 2) to identify new methods, strategies and technologies for improving the diagnosis and prognostication of endocrine neoplasms, and 3) to develop methods for personalized precision treatment of endocrine tumors.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Genetics and Genomics, Molecular Biology and Biochemistry

Selected Recent Publications

  1. Sadowski SM, Pusztaszeri M, Brulhart-Meynet MC, Petrenko P, De Vito C, Sobel J, Delucinge-Vivier C, and Kebebew E, Regazzi R, Philippe J, Triponez F, Dibner C.
    J Clin Endocrinol Metab. 103(6): 2189-2198, 2018. [ Journal Article ]
  2. Tirosh A, Sadowski SM, Linehan WM, Libutti SK, Patel D, Nilubol N, and Kebebew E.
    JAMA Oncol. 4(1): 124-126, 2018. [ Journal Article ]
  3. Sadowski SM, Neychev V, Millo C, Shih J, Nilubol N, Herscovitch P, Pacak K, Marx SJ, and Kebebew E.
    J Clin Oncol. 34(6): 588-96, 2016. [ Journal Article ]
  4. Sadowski, SM, Millo C, Neychev V, Aufforth R, Keutgen X, Glanville J, Alimchandani M, Nilubol N, Herscovitch P, Quezado M, and Kebebew E.
    Ann Surg Oncol. 22(suppl 3): S676-82, 2015. [ Journal Article ]
  5. Sadowski SM, Boufraqech M, Zhang L, Mehta A, Kapur P, Zhang Y, Li Z, Shen M, and Kebebew E.
    Oncotarget. 6(20): 18038-49, 2015. [ Journal Article ]

Dr. Sadowski received her medical training at the University of Geneva, Switzerland. She completed her general surgery residency training at the University Hospitals of Geneva and received a master's degree in medical biostatistics at the University of Montreal, Canada. She completed her endocrine oncology surgery fellowship at the National Institutes of Health. Dr. Sadowski was on faculty at the University Hospitals of Geneva before being recruited to the NCI.


Name Position
Bhargav Prasad Earla Postbaccalaureate Fellow
James P. Madigan, Ph.D. Staff Scientist
Rupali Sharma, Ph.D. Postdoctoral Fellow (CRTA)