James P. Madigan, Ph.D.

James P. Madigan, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgical Oncology Program


Dr. Madigan is a staff scientist in the laboratory of Samira Sadowski, within the Surgical Oncology Program. He is currently working on uncovering novel driver events and signaling pathways of neuroendocrine tumors (NETs). His research is focussed on expanding our knowledge base regarding the role of abberent epigenetic changes in NETs, which appear to be particularly important for their pathogenesis and progression. Dr. Madigan is also using gene loss-of-function and small molecule inhibitory screens to better inform on focused targeted therapy for NET patients.

Areas of Expertise

1) cell signaling 2) signaling pathway analysis 3) protein-protein interactions 4) post-translational modifications 5) chemoresistance


Selected Key Publications

A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer.

Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW.
Exp Cell Res. 388(2): 111860, 2020. [ Journal Article ]

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding

Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y.
J Biol Chem. 293(42): 16142-16159, 2018. [ Journal Article ]

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation

Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD.
Biochem J. 424(1): 153-61, 2009. [ Journal Article ]

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS.
Proc Natl Acad Sci U S A. 102(36): 12879-84, 2005. [ Journal Article ]

DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis

Madigan JP, Chotkowski HL, Glaser RL.
Nucleic Acids Res. 30(17): 3698-705, 2002. [ Journal Article ]