Y.S. Robert Cheng, D.V.M., Ph.D.

Y.S. Robert Cheng, D.V.M., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Cheng's research focuses on identifying the early epigenetic changes that may contribute to cancer risk in a DMBA-induced rat mammary gland cancer model. He is using global RNA expression fingerprint profiling during the early stage of breast cancer development and comparing this data to results from parallel epigenetic studies. Dr. Cheng is also interested in elucidation of the mechanistic role of both phase I and II detoxification enzymes in this cancer model.

Areas of Expertise

Cancer Immunology And Immunotherapy
Cancer Biology


Selected Publications

Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives

Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, Heinecke JL, Holland RJ, Ridnour LA, Caceres VM, Spadari-Bratfisch RC, Paolocci N, Velázquez-Martínez CA, Wink DA, Miranda KM.
J. Med. Chem.. 56: 7804-20, 2013. [ Journal Article ]

Dithiolethiones inhibit NF-?B activity via covalent modification in human estrogen receptor-negative breast cancer

Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.
Cancer Res.. 72: 2394-404, 2012. [ Journal Article ]

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer

Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.
Breast Cancer Res.. 14: R125, 2012. [ Journal Article ]

Alterations of the lung methylome in allergic airway hyper-responsiveness

Cheng RY, Shang Y, Limjunyawong N, Dao T, Das S, Rabold R, Sham JS, Mitzner W, Tang WY.
Environ. Mol. Mutagen.. 55: 244-55, 2014. [ Journal Article ]

Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity

Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA.
Clin. Cancer Res.. 19: 1340-6, 2013. [ Journal Article ]