Wendy D. DuBois

Wendy D. DuBois

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cancer Biology and Genetics


The LCBG Animal Model and Genotyping Facility provides outstanding, reliable research support to a number of NCI intramural investigators. The Facility's mission is to create and maintain mouse models for various cancers including: - B cell lymphomas, - plasma cell tumors, - myeloma, - skin carcinogenesis and melanoma, - breast cancer, and - prostate cancer. The Core also performs a variety of genomic analyses in support of investigators.

Areas of Expertise

Experiment Design
Colony Management


Selected Publications

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T.
Cell Rep. 4: 913-20, 2013. [ Journal Article ]

cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma.

He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, Huang J.
Stem Cell Reports. June 6: 1630-1644, 2017. [ Journal Article ]

Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation.

Simmons JK, Michalowski AM, Gamache BJ, DuBois W, Patel J, Zhang K, Gary J, Zhang S, Gaikwad S, Connors D, Watson N, Leon E, Chen JQ, Kuehl WM, Lee MP, Zingone A, Landgren O, Ordentlich P, Huang J, Mock BA.
Mol Cancer Ther . May 18: 2017. [ Journal Article ]

MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.

Cataisson C, Michalowski AM, Shibuya K, Ryscavage A, Klosterman M, Wright L, Dubois W, Liu F, Zhuang A, Rodrigues KB, Hoover S, Dwyer J, Simpson MR, Merlino G, Yuspa SH.
Sci Signal. Jun 21:9(433): 2016. [ Journal Article ]

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, Dubois W, Nelson S, Vian L, Oliveira TY, Jankovic M, Hakim O, Gazumyan A, Pavri R, Awasthi P, Song B, Liu G, Chen L, Zhu S, Feigenbaum L, Staudt L, Murre C, Ruan Y, Robbiani DF, Pan-Hammarström Q, Nussenzweig MC, Casellas R.
Cell. Dec18;159(7): 1524-37, 2014. [ Journal Article ]


Animal Technician (Contr.)
Marta Custer
Animal Technician (Contr.)
Maudeline Etienne
Biological Laboratory Technician
Anthony Vieira
Biological Laboratory Technician
Tina Wellington
Celina photo
Celina Williams