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Travis Stracker photo.

Travis H. Stracker, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Travis Stracker’s research focuses on understanding how cells respond to DNA damage and maintain genomic stability. Defects in the cellular response to DNA damage underlie rare diseases associated with cancer predisposition and are exploitable vulnerabilities for cancer therapy. The lab uses a variety of approaches to further understand the signal transduction pathways triggered by radio and chemotherapy and to identify new therapeutic targets.

Areas of Expertise

1) DNA damage response 2) chromosomal instability 3) DNA repair 4) chromatin assembly 5) microcephaly 6) synthetic lethality

Publications

Selected Recent Publications

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells

Josep Biayna, Isabel Garcia-Cao, Miguel M. Álvarez, Marina Salvadores, Jose Espinosa-Carrasco, Marcel McCullough, Fran Supek, Travis H. Stracker
PLoS Biology. Mar 31;19(3):e3001176: 2021.
Full-Text Article
[ Journal Article ]

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

SandraSegura-Bayona, MarinaVillamor-Payà, Camille Stephan-OttoAttolini, Lars M.Koenig, MariaSanchiz-Calvo, Simon J.Boulton, Travis H.Stracker
Cell Reports. Aug 4;32(5):107983: 2021.
Full-Text Article
[ Journal Article ]

The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease

Segura-Bayona S, Stracker TH.
Cell Mol Life Sci. 76(19): 3827-3841, 2019. [ Journal Article ]

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Lee SB, Segura-Bayona S, Villamor-Payà M, Saredi G, Todd MAM, Attolini CS, Chang TY, Stracker TH, Groth A.
Sci Adv. 4(8): eaat4985, 2018. [ Journal Article ]

Molecular basis of Tousled-Like Kinase 2 activation

Mortuza GB, Hermida D, Pedersen AK, Segura-Bayona S, López-Méndez B, Redondo P, Rüther P, Pozdnyakova I, Garrote AM, Muñoz IG, Villamor-Payà M, Jauset C, Olsen JV, Stracker TH, Montoya G.
Nat Commun. 9(1): 2535, 2018. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Jordann Smak photo.
Postdoctoral Fellow (CRTA)
Jordann Smak, Ph.D.
Shalu Sharma photo.
Postdoctoral Fellow (visiting)
Shalu Sharma, Ph.D.
Marina Villamor-Paya photo.
Postdoctoral Fellow (visiting)
Marina Villamor-Paya, Ph.D.
Simran Khurana photo.
Staff Scientist
Simran Khurana, Ph.D.
Postdoctoral Fellow (CRTA)
Alana Sherker, Ph.D.
Toba Osagie photo.
Pre-doctoral Visiting Fellow (graduate student, co-supervised with Dr. Citrin)
Toba Osagie, MSc, MRes