Takeo Fujii, M.D., M.P.H.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 1044A
- Bethesda, MD 20892
- 240-858-3007
- takeo.fujii@nih.gov
RESEARCH SUMMARY
Dr. Fujii is a medical oncologist and a physician-scientist who specializes in breast cancer and metastasis. His research focuses on finding novel therapeutic targets to breast cancer brain metastasis by understanding the role of inflammation and immune cells in the tumor microenvironment.
Areas of Expertise
Takeo Fujii, M.D., M.P.H.
Research
The goal of my research is to develop drugs by discovering therapeutic targets through basic translational research and early-phase clinical trials for patients with breast cancer.
My objectives are to: (1) identify the roles of inflammation and thrombosis in breast cancer brain metastasis, (2) preclinically validate potential therapeutic targets and (3) design and lead early-phase clinical trials.
I use a mouse model to help me comprehensively understand the tumor microenvironment in the brain and transcriptomic changes of breast cancer brain metastasis. In my mouse model, stroke promotes breast cancer brain metastasis. I am also interested in the interaction between deep vein thrombosis (DVT), which is the most common thrombosis in patients with cancer, and circulating immune cells and the effects on breast cancer metastasis. My work also seeks to describe the immune cell landscape in primary breast tumors, metastatic breast tumors, hematopoietic stem cells and/or progenitor cells. Particularly, I focus on components of the innate immune system such as neutrophils, neutrophil extra cellular traps (NETs) and monocytes.
Publications
Treatment with Granulocyte-colony Stimulating Factor (G-CSF) is not associated with Increased Risk of Brain Metastasis in Patients with De Novo Stage IV Breast Cancer
Androgen receptor expression on circulating tumor cells in metastatic breast cancer
Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers
Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer
Effectiveness of an Adjuvant Chemotherapy Regimen for Early-Stage Breast Cancer: A Systematic Review and Network Meta-analysis
Biography
Takeo Fujii, M.D., M.P.H.
Dr. Fujii received his M.D. from the Shinshu University School of Medicine, Japan, and an M.P.H. from the University of Texas Health Science Center at Houston School of Public Health, during which he was a graduate research assistant at the Department of Breast Medical Oncology in the MD Anderson Cancer Center. He completed internal medicine and medical oncology training at St. Luke’s International Hospital, Japan. Further, he completed advanced clinical fellowship in the Phase I Clinical Trials Program in the Department of Investigational Cancer Therapeutics at MD Anderson Cancer Center, TX, internal medicine residency at the University of Hawaii, and a medical oncology fellowship in the Translational Research Track at the Northwell Health Cancer Institute and Cold Spring Harbor Laboratory joint program, NY, where he trained in Dr. Mikala Egeblad’s laboratory.
He joined the Women's Malignancies Branch as a Physician-Scientist Early Investigator in 2022.
Job Vacancies
We have no open positions in our group at this time, please check back later.
To see all available positions at CCR, take a look at our Careers page. You can also subscribe to receive CCR's latest job and training opportunities in your inbox.
News
Learn more about CCR research advances, new discoveries and more
on our news section.