Sukbir Kaur, Ph.D.

Sukbir Kaur, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


Exosomes or extracellular vesicles (EVs) are shed by all kinds of cells, and recent research has shown that exosomes play a major role in cell-cell communication and also are associated with disease progression such as cancer metastasis. Dr. Kaur discovered that CD47, which is known as the “don’t eat me” signal and which is upregulated in many cancers, is also present on exosomes. Her major interest is to explore the role of exosome-associated CD47 in breast and prostate cancers.

Areas of Expertise

Exosomes/extracellualr Vesicles
Cancer Stem Cells
MiRNA Biogenesis
RNA Sequencing Data Analysis
Molecular And Cell Biology
Small Non-coding RNAs


Selected Key Publications

CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs

Kaur S, Elkahloun AG, Arakelyan A, Young L, Myers TG, Otaizo-Carrasquero F, Wu W, Margolis L, Roberts DD.
Sci Rep. 8(1): 2577, 2018. [ Journal Article ]

A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

Kaur S, Elkahloun AG, Singh SP, Chen QR, Meerzaman DM, Song T, Manu N, Wu W, Mannan P, Garfield SH, Roberts DD.
Oncotarget. 7(9): 10133-52, 2016. [ Journal Article ]

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

Kaur S, Singh SP, Elkahloun AG, Wu W, Abu-Asab MS, Roberts DD.
Matrix Biol. 37: 49-59, 2014. [ Journal Article ]

Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors

Kaur S, Soto-Pantoja DR, Stein EV, Liu C, Elkahloun AG, Pendrak ML, Nicolae A, Singh SP, Nie Z, Levens D, Isenberg JS, Roberts DD.
Sci Rep. 3: 1673, 2013. [ Journal Article ]

Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47

Kaur S, Martin-Manso G, Pendrak ML, Garfield SH, Isenberg JS, Roberts DD.
J Biol Chem. 285(50): 38923-32, 2010. [ Journal Article ]