Stuart H. Yuspa, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 4068A1
- Bethesda, MD 20892
Dr. Yuspa focused his research on understanding mechanisms of the pre-metastatic stages of cancer pathogenesis. Using the model of skin carcinogenesis, his work delineated the biochemistry associated with oncogenic RAS-induced benign squamous neoplasia and the multistep progression to squamous cell carcinoma. The findings reflect squamous cell cancer development in multiple internal lining epithelia and the interaction of cancer cells with the microenvironment.
As an NIH Scientist Emeritus, Dr. Yuspa participates in a large, interactive basic cancer research laboratory utilizing state-of-the-art approaches to understand cancer pathogenesis and progression in multiple target sites with the goal of translating discoveries into clinical advances.
Areas of Expertise
1) skin 2) keratinocytes 3) RAS 4) squamous cancer 5) CLIC4 6) inflammation
RAS induced senescence of skin keratinocytes is mediated through Rho-associated protein kinase (ROCK)
Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4
Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin
T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis
Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas
Stuart H. Yuspa, M.D.
Dr. Yuspa received his B.S. from Johns Hopkins University and his M.D. from the University of Maryland Medical School. He completed his internship and residency at the Hospital of the University of Pennsylvania and has been a senior investigator at the NCI since 1972. Among his honors are the Lila Gruber Award of the American Academy of Dermatology and the Clowes Award from the American Association for Cancer Research. Dr. Yuspa is author of more than 400 publications in the fields of carcinogenesis and epithelial differentiation.
Dr. Yuspa retired in December 2021 and is now an NIH Scientist Emeritus.