Stuart H. Yuspa, M.D.

Stuart H. Yuspa, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Yuspa focused his research on understanding mechanisms of the pre-metastatic stages of cancer pathogenesis. Using the model of skin carcinogenesis, his work  delineated the biochemistry associated with oncogenic RAS-induced benign squamous neoplasia and the multistep progression to squamous cell carcinoma. The findings reflect squamous cell cancer development in multiple internal lining epithelia and the interaction of cancer cells with the microenvironment.

As an NIH Scientist Emeritus, Dr. Yuspa participates in a large, interactive basic cancer research laboratory utilizing state-of-the-art approaches to understand cancer pathogenesis and progression in multiple target sites with the goal of translating discoveries into clinical advances.

Areas of Expertise

1) skin 2) keratinocytes 3) RAS 4) squamous cancer 5) CLIC4 6) inflammation


Selected Recent Publications

RAS induced senescence of skin keratinocytes is mediated through Rho-associated protein kinase (ROCK)

Lee AJ, Fraser E, Flowers B, Kim J, Wong K, Cataisson C, Liu H, Yang H, Lee MP, Yuspa SH, Li L
Molecular Carcinogenesis. 60(12): 799-812, 2021.
Full-Text Article
[ Journal Article ]

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4

Carofino BL, Dinshaw KM, Ho PY, Cataisson C, Michalowski AM, Ryscavage A, Alkhas A, Wong NW, Koparde V, Yuspa SH.
Oncotarget. 10(68): 7251-75, 2019. [ Journal Article ]

Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin

Li L, Cataisson C, Flowers B, Fraser E, Sanchez V, Day CP, Yuspa SH.
J Invest Dermatol. 139(7): 1506-15, 2019. [ Journal Article ]

T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis

Cataisson C, Salcedo R, Michalowski AM, Klosterman M, Naik S, Li L, Pan MJ, Sweet A, Chen JQ, Kostecka LG, Karwan M, Smith L, Dai RM, Stewart CA, Lyakh L, Hsieh WT, Khan A, Yang H, Lee M, Trinchieri G, Yuspa SH.
Mol Cancer Res. 17(8): 1759-73, 2019. [ Journal Article ]

Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas

Mascia F, Schloemann DT, Cataisson C, McKinnon KM, Krymskaya L, Wolcott KM, Yuspa SH.
Int J Cancer. 139(11): 2593-7, 2016. [ Journal Article ]