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Stan Adoro

Stanley Adoro, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch

RESEARCH SUMMARY

Dr. Adoro is an immunologist with an interest in understanding the process of blood cell development. His laboratory seeks to understand how the mechanisms that sense and maintain cellular proteome homeostasis (“proteostasis”) control hematopoietic cell development and function. These studies are revealing that the dysfunction of key proteostasis regulators impairs stem and blood cell integrity and contributes to the emergence of diseases including blood cancers, chronic infection and organismal growth defects.

Areas of Expertise

1) hematopoietic stem and progenitor cells 2) hematopoiesis 3) blood cancer 4) proteostasis 5) posttranslational regulation of immune cells

Publications

Selected Key Publications

Notch-induced endoplasmic reticulum- associated degradation governs mouse thymocyte β-selection

Liu X, Yu J, Xu L, Umphred-Wilson K, Peng F, Ding Y, Barton BM, Lv X, Zhao MY, Sun S, Hong Y, Qi L, Adoro S*, Chen X*. *Corresponding authors
Elife. 10: e69975, 2021. [ Journal Article ]

Post-translational control of T cell development by the ESCRT protein CHMP5

Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH.
Nat Immunol. 18(7): 780-790, 2017. [ Journal Article ]

Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

Liu C, Chen Q, Shang Y, Chen L, Myers J, Awadallah A, Sun J, Yu S, Umphred-Wilson K, Che D, Dou Y, Li L, Wearsch P, Ramírez-Bergeron D, Beck R, Xin W, Jin G, Adoro S, Zhou L.
Theranostics. 12(6): 2894-2907, 2022. [ Journal Article ]

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X.
Nat Cell Biol. 22(10): 1162-1169, 2020. [ Journal Article ]

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH.
Nat Commun. 6: 7562, 2015. [ Journal Article ]

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