Sikandar G. Khan, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 4002
- Bethesda, MD 20892
- 301-594-5268
- skhan@helix.nih.gov
RESEARCH SUMMARY
Dr. Khan is engaged in studies that focus on the molecular, cellular, and clinical features of human genetic diseases such as xeroderma pigmentosum, a cancer-prone recessive disease, and trichothiodystrophy, a multi-system disorder. The aim is to define the molecular defects associated with these diseases. These studies have revealed the significance of DNA repair in protection against cancer, neurological abnormalities and developmental defects. A more in-depth understanding of the pathophysiology of these diseases may lead to new strategies for therapeutic intervention of these diseases in affected patients as well as in the general population.
Areas of Expertise
Sikandar G. Khan, Ph.D.
Research
Dr. Khan is engaged in studies that focus on the molecular, cellular, and clinical features of human genetic diseases such as xeroderma pigmentosum, a cancer-prone recessive disease, and trichothiodystrophy, a multi-system disorder. The aim is to define the molecular defects associated with these diseases. These studies have revealed the significance of DNA repair in protection against cancer, neurological abnormalities and developmental defects. A more in-depth understanding of the pathophysiology of these diseases may lead to new strategies for therapeutic intervention of these diseases in affected patients as well as in the general population.
Publications
Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons
XPC branch-point sequence mutations disrupt U2 snRNP binding, resulting in abnormal pre-mRNA splicing in xeroderma pigmentosum patients
The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function
High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients
Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum
Biography
Sikandar G. Khan, Ph.D.
Dr. Khan received his Ph.D. in biochemistry in 1989 from AMU Aligarh, India, for his research work at the Industrial Toxicology Research Centre, Council of Scientific and Industrial Research, Lucknow, India, in the area of 'Interaction of particulate air pollutants with biological macromolecules'. He has a keen interest in exploring the molecular mechanisms involved in genotype-phenotype correlations in DNA repair-deficient patients with and without skin cancer risks. Dr. Khan received an NIH postdoctoral fellowship (NIH training grant T-AR-07569) and completed his postdoctoral training in the Department of Dermatology at Case Western Reserve University, Cleveland, OH (1991-1993). In 1993 he received the Dermatology Foundation's Neutrogena Dermatologics Cancer Research Award. Dr. Khan is a member of the Society for Investigative Dermatology.