Ross Lake Headshot

Ross Lake

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cancer Biology and Genetics


Ross Lake is the head of the Laboratory of Cancer Biology and Genetics (LCBG) Microscopy Core Facility, which provides state-of-the-art equipment, materials, and expertise to researchers in the LCBG. In addition, the Core is open to scientists at the National Cancer Institute. The Core instruments include a Carl Zeiss LSM780 laser scanning confocal microscope, two Carl Zeiss AxioScan Z1 slide scanners, an automated Nikon Ti2 Eclipse widefield microscope, and a Carl Zeiss AxioObserver epifluorescent microscope. The Core provides access to cutting-edge technology and training on the Core's instruments as well as assistance with experimental design.

Areas of Expertise



Selected Recent Publications

Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration

Ward Y*, Lake R*, Faraji F, Sperger J, Martin P, Gilliard C, Ku KP, Rodems T, Niles D, Tillman H, Yin J, Hunter K, Sowalsky AG, Lang J, Kelly K. (*co-first author)
Cell Reports. 23(3): 808-822, 2018. [ Journal Article ]

A novel structure associated with aging is augmented in the DPP6-KO mouse brain

Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA
Acta Neuropathol Commun. Nov 23;8(1):19: 10.1186/s40478-020-01065-7, 2020. [ Journal Article ]

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Jansen CS, Prokhnevska N, Master VA, Sanda MG, Carlisle JW, Bilen MA, Cardenas M, Wilkinson S, Lake R, Sowalsky AG, Valanparambil RM, Hudson WH, McGuire D, Melnick K, Khan AI, Kim K, Chang YM, Kim A, Filson CP, Alemozaffar M, Osunkoya AO, Mullane P, Ellis C, Akondy R, Im SJ, Kamphorst AO, Reyes A, Liu Y, Kissick H
Nature. Dec;576(7787): 465-470, 2019. [ Journal Article ]

EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis

Li L, Ameri AH, Wang S, Jansson KH, Casey OM, Yang Q, Beshiri ML, Fang L, Lake R, Agarwal S, Alilin AN, Xu W, Yin J, Kelly K.
Oncogene. Aug;38(35): 6241-6255, 2019. [ Journal Article ]

CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model

Ward Y*, Lake R*, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K. (*co-first author)
Oncogene. 32: 2726-2738, 2013. [ Journal Article ]