Breadcrumb

Pedro J. Batista, Ph.D.

Pedro J. Batista, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cell Biology

RESEARCH SUMMARY

Research in the Batista lab aims to understand how the RNA epigenome modulates gene expression during development and in disease. Dr. Batista demonstrated that N6-methyl-adenosine (m6A), the most abundant RNA post-transcriptional modification found on mRNAs and long intergenic noncoding RNAs (lncRNAs), determines transcriptome flexibility and modulates the balance between pluripotency and differentiation. We want to understand at the molecular level how interactions between cellular environment and the RNA epigenome impact the RNA-centric regulatory networks that control cell identity, and how disruption of such pathways contribute to the establishment and proliferation of cancer.

Areas of Expertise

1) RNA biology 2) post-transcriptional regulation 3) epitranscriptomics 4) stem cell biology 5) non-coding RNAs

Publications

Selected Recent Publications

An epitranscriptomic vulnerability in myeloid malignancies

Schmiechen AC, Batista PJ.
Nat Med. 23(11): 1252-54, 2017. [ Journal Article ]

Structural imprints in vivo decode RNA regulatory mechanisms

Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung J-W, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, and Chang HY.
Nature. 519: 486–490, 2015. [ Journal Article ]

Structure and Thermodynamics of N6-methyladenosine in RNA: a Spring-loaded Base Modification

Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, and Kool ET.
J Am Chem Soc. 137: 2107–2115, 2015. [ Journal Article ]

It's complicated… m6A-dependent regulation of gene expression in cancer

Fitzsimmons CM, Batista PJ.
Biochim Biophys Acta Gene Regul Mech. 1862(3): 382-93, 2019. [ Journal Article ]

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

Batista PJ and Chang HY.
Cell. 152: 1298–1307, 2013. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - RNA biology Ph.D. or equivalent, M.D. or equivalent Pedro J. Batista pedro.batista@nih.gov

Team

Postdoctoral Fellow (CRTA)
Dalen Chan, Ph.D.
Postdoctoral Fellow (CRTA)
Christina Fitzsimmons, Ph.D.
Biologist
Mariana D. Mandler, Ph.D.
Postbaccalaureate Fellow
Hiep Tai Nguyen
Postbaccalaureate Fellow
Siddhardha Maligireddy
Post-postbaccalaureate Fellow
Andrew Saiz