Paul A. Roche, Ph.D.

Paul A. Roche, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch


Dr. Roche uses molecular and cellular approaches to study to cell biology of lymphocyte activation by antigen presenting cells. More specifically, his work attempts to understand how dendritic cells, and other antigen presenting cells, generate and present peptide fragments of internalized foreign antigens to CD4 T cells. Antigen processing and presentation of MHC class II-peptide complexes to specific T cells is important for T cell development/selection as well as the ability of animals to mount immune responses to destroy foreign pathogens in the body.

Areas of Expertise

Antigen Presentation
Dendritic Cell
CD T Cell


Selected Recent Publications

The ins and outs of MHC class II-mediated antigen processing and presentation

Roche PA, Furuta, K
Nature Rev Immunol. 15: 1-14, 2015. [ Journal Article ]

Suppression of antigen presentation by IL-10

Mittal SK, Roche PA
Curr Opin Immunol. 34: 22-27, 2015. [ Journal Article ]

TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM
Cell. 158: 506-521, 2014. [ Journal Article ]

The ins and outs of MHC class II-mediated antigen processing and presentation

Roche PA, Furuta K.
Nat Rev Immunol. 15(4): 203-16, 2015. [ Journal Article ]

Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells

Cho KJ, Walseng E, Ishido S, Roche PA.
Proc Natl Acad Sci U S A. 112(33): 10449-54, 2015. [ Journal Article ]

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