Ming Sun, Ph.D.
- Center for Cancer Research
- National Cancer Institute
RESEARCH SUMMARY
Dr. Sun received his Ph. D. at Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. He has been a Cell & Molecular Biology Section member since 2016 and is currently a Research Fellow. Dr. Sun is mainly focused on understanding the underlying mechanism of tumorigenesis and heterogenicity of neuroblastoma (NB). Dr. Sun found that dysregulation of the Chromosomal Passenger Complex (CPC) subunit INCENP contributes to neuroblastoma tumorigenesis and targeting INCENP presents a novel strategy to disrupt the activity of CPC and inhibit neuroblastoma progression. Additionally, Dr. Sun has successfully generated adrenergic (ADRN) and mesenchymal (MES) NB subpopulations from several patient-derived xenografts (PDXs) of NB. Through multi-omics approaches, Dr. Sun aims to identify potential therapeutic strategies to target these heterogeneous subpopulations in NB tumors.