Michael Maurizi, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 2128B
- Bethesda, MD 20892-4256
- 240-760-7217
- mmaurizi@helix.nih.gov
RESEARCH SUMMARY
Dr. Maurizi conducted seminal studies uncovering the presence and importance of multi-component ATP-dependent proteases in bacterial cells. His biochemical and structural studies of Clp protease complexes helped generate current models of the mechanism by which these and other molecular machines recognize, unfold, and degrade intracellular proteins. Current research is focused on N-end rule degradation as a major pathway for cellular protein quality control. As Head of the Biochemistry of Proteins Section Dr. Maurizi directed a multi-disciplinary research program that combined genetics, biochemistry, and high-resolution structural analysis to study the regulatory pathways in which intracellular proteolysis plays a major role and the properties and behavior of the molecular machines that carry out ATP-dependent proteolysis.
Areas of Expertise
Biography
Michael Maurizi, Ph.D.
Dr. Maurizi received his Ph.D. in biochemistry from the University of Illinois and completed postdoctoral studies with Earl Stadtman and Ann Ginsburg in the National Heart, Lung, and Blood Institute at the NIH. Dr. Maurizi began his work on energy-dependent proteases in collaboration with Susan Gottesman in the Laboratory of Molecular Biology, NCI, before joining the staff of the Laboratory of Cell Biology in 1991.
Dr. Maurizi retired as a Senior Investigator in 2016 and is now an NIH Scientist Emeritus.