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Michael  Maurizi, Ph.D.

Michael Maurizi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cell Biology

RESEARCH SUMMARY

Dr. Maurizi conducted seminal studies uncovering the presence and importance of multi-component ATP-dependent proteases in bacterial cells. His biochemical and structural studies of Clp protease complexes helped generate current models of the mechanism by which these and other molecular machines recognize, unfold, and degrade intracellular proteins. Current research is focused on N-end rule degradation as a major pathway for cellular protein quality control. As Head of the Biochemistry of Proteins Section Dr. Maurizi directed a multi-disciplinary research program that combined genetics, biochemistry, and high-resolution structural analysis to study the regulatory pathways in which intracellular proteolysis plays a major role and the properties and behavior of the molecular machines that carry out ATP-dependent proteolysis.

Areas of Expertise

1) protein biochemistry 2) ATP-dependent protein degradation 3) post-translational regulation 4) protein quality control 5) bacterial stress responses 6) mitochondrial stress responses

Publications

Selected Recent Publications

Mitochondrial ClpP activity is required for cisplatin resistance in human cells

Yang Zhang and Micheal R. Maurizi
Biochim Biophys Acta. 77: 252-264, 2016. [ Journal Article ]

Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis

Li M, Kandror O, Akopian T, Dharkar P, Wlodawer A, Maurizi MR, Goldberg AL
J Biol Chem. 291: 7465-7476, 2016. [ Journal Article ]

ClpX shifts into high gear to unfold stable proteins

Maurizi MR, Stan G.
Cell. 155: 502-4, 2013. [ Journal Article ]

The N-degradome of Escherichia coli: limited proteolysis in vivo generates a large pool of proteins bearing N-degrons

Humbard MA, Surkov S, De Donatis GM, Jenkins L, Maurizi MR.
J. Biol. Chem. 2013. [ Journal Article ]

4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells

Kang JH, Chang YC, Maurizi MR.
J. Biol. Chem. 287: 15661-71, 2012. [ Journal Article ]