Michael J. Kruhlak, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room B114E
- Bethesda, MD 20892
- 240-858-3342
- kruhlakm@mail.nih.gov
Associate Scientist
Head, CCR Confocal Microscopy Core Facility
RESEARCH SUMMARY
Dr. Kruhlak directs the activities of the CCR Confocal Microscopy Core that supports the light microscopy imaging needs of NCI researchers. This includes developing novel imaging-based assays based on high-resolution confocal, multi-photon, and super-resolution imaging methods.Areas of Expertise
Confocal Microscopy
Multi-photon Imaging
Airyscan Super-resolution
Structured Illumination Microscopy
Live Cell Imaging
Lightsheet Microscopy
Michael J. Kruhlak, Ph.D.
Publications
- Bibliography Link
- View Dr. Kruhlak's PubMed Summary
Selected Key Publications
Generation of tumor antigen-specific iPSC-derived thymic emigrants using a 3D thymic culture system
Cell Reports.
22(12):
3175-3190,
2018.
[ Journal Article ]
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis
Nature Medicine.
23(10):
1176-1190,
2017.
[ Journal Article ]
A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance
Cell Reports.
8(4):
1049-1062,
2014.
[ Journal Article ]
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Nature.
447(7145):
730-734,
2007.
[ Journal Article ]
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
Journal of Cell Biology.
172(6):
823-834,
2006.
[ Journal Article ]
Biography
Associate Scientist
Michael J. Kruhlak, Ph.D.
Dr. Kruhlak received his Ph.D. from the Department of Biochemistry and Molecular Biology at the University of Calgary Medical School. Â From there, in 2001, he joined the NCI as a staff scientist to head the Experimental Immunology Branch Light Microscopy and Digital Imaging Facility. In 2018, as a NCI associate scientist he became director of the CCR Confocal Microscopy Core.
