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Martin J. Schnermann, Ph.D.

Martin J. Schnermann, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Chemical Biology Laboratory

RESEARCH SUMMARY

The Schnermann lab uses the tools and concepts of modern organic chemistry to discover new molecules for cancer drug delivery and imaging. In the context of drug delivery, we develop innovative chemical strategies to deliver bioactive payloads with high precision. In the area of imaging, we create novel fluorescent molecules with improved properties for in vivo optical imaging and microscopy. While our studies are enabled by core expertise in organic synthesis and molecular design, trainees in the lab are engaged in highly interdisciplinary research using techniques that range from in vitro characterization to in vivo imaging. We embrace a highly collaborative approach with extensive interactions with both intramural and extramural investigators.

Areas of Expertise

1) complex molecule synthesis 2) synthetic methodology 3) near-IR fluorescence 4) natural product chemistry 5) drug discovery 6) drug delivery

Publications

Selected Key Publications

Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery

Gorka AP, Nani RR, Schnermann MJ.
Acc Chem Res. 51(12): 3226-35, 2018. [ Journal Article ]

Norcyanine-Carbamates Are Versatile Near-Infrared Fluorogenic Probes

Usama, SM, Inagaki, F, Kobayashi, H, Schnermann, MJ
J Am Chem Soc. 143/15: 5674-5679, 2021. [ Journal Article ]

In vivo activation of duocarmycin–antibody conjugates by near-infrared light

Nani RR, Gorka AP, Nagaya T, Yamamoto T, Ivanic J, Kobayashi H, Schnermann MJ
ACS Central Science. 3: 329–337, 2017. [ Journal Article ]

Cyanine conformational restraint in the far-red range

Michie MS, Götz R, Franke C, Bowler M, Kumari N, Magidson V, Levitus M, Loncarek J, Sauer M, Schnermann MJ
J Am Chem Soc. 139: 12406-12409, 2017. [ Journal Article ]

Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines

Bandi V, Luciano M P, Saccomano M, Patel N P, Bischof T S, Lingg J, Tsrunchev P, Nix M, Ruehle B, Sanders C, Riffle L, Robinson C, Difilippantonio S, Kalen J, Resch-Genger U, Ivanic J, Bruns O, Schnermann M
Nature Methods. 19: 353-358, 2022.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Organic synthesis, chemical biology Ph.D. or equivalent Martin Schnermann martin.schnermann@nih.gov

Team

Postdoctoral Fellow
Siddharth Matikonda, Ph.D.
Postdoctoral Fellow
Melissa Lucero, PhD
Postdoctoral Fellow
Syed Usama, PhD
Postdoctoral Fellow
Pradeep Shrestha, PhD
Postdoctoral Fellow
Donghao Li, PhD
Postdoctoral Fellow
Sierra Marker, PhD
Postdoctoral Fellow
Shivaji Edupuganti, PhD

Covers

cover image for chemical science

Core remodeling leads to long wavelength fluoro-coumarins

Published Date

Low molecular weight, uncharged far-red and NIR dyes would be enabling for a range of imaging applications. Rational redesign of the coumarin scaffold leads to Fluoro-Coumarins (FCs), the lowest molecular weight dyes with emission maxima beyond 700, 800, and 900 nm. FCs display large Stokes shifts and high environmental sensitivity, with a 40-fold increase in emission intensity in hydrophobic solvents. Untargeted variants exhibit selective lipid droplet and nuclear staining in live cells. Furthermore, sulfo-lipid derivatization enables active targeting to the plasma membrane. Overall, these studies report a promising platform for the development of biocompatible, context-responsive imaging agents.

Citation

See: Core remodeling leads to long wavelength fluoro-coumarins by Siddharth S. Matikonda, Joseph Ivanic, Miguel Gomez, Gabrielle Hammersley and  Martin J. Schnermann in Chemical Science, 202011, 7302-7307.

Cover of Organic & Biomolecular Chemistry, Jul 28, 2015

Cyanine polyene reactivity: scope and biomedical applications

Published Date

Cyanines are indispensable fluorophores that form the chemical basis of many fluorescence-based applications. A feature that distinguishes cyanines from other common fluorophores is an exposed polyene linker that is both crucial to absorption and emission and subject to covalent reactions that dramatically alter these optical properties. Over the past decade, reactions involving the cyanine polyene have been used as foundational elements for a range of biomedical techniques. These include the optical sensing of biological analytes, super-resolution imaging, and near-IR light-initiated uncaging. This review surveys the chemical reactivity of the cyanine polyene and the biomedical methods enabled by these reactions. The overarching goal is to highlight the multifaceted nature of cyanine chemistry and biology, as well as to point out the key role of reactivity-based insights in this promising area.

Citation

 See: Cyanine polyene reactivity: scope and biomedical applications by Alexander P. Gorka, Roger R. Nani and Martin J. Schnermann in Organic & Biomolecular Chemistry201513, 7584-7598.