Mark J. Roth, M.D.

Mark J. Roth, M.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10, Room 2S235K
  • Bethesda, MD 20892
  • 301-480-7430
Laboratory of Pathology


Mark Roth provides routine, daily clinical cytopathology service to the NIH community and teaches anatomic pathology residents and cytopathology fellows in the Laboratory of Pathology, He provides cytology services to support the research endeavors of NIH principal investigators and the Cytopathology Section. He applies his expertise in cytopathology and molecular pathology to develop new approaches to advance the diagnostic, prognostic and therapeutic accuracy of patient samples obtained by minimally invasive techniques such as those used to obtain cytology samples.

Areas of Expertise

Anatomic Pathology
Molecular Biology
Cancer Early Detection, Screening And Etiology
Translational And Population-based Research


Selected Key Publications

Cytologic detection of esophageal squamous cell carcinoma and precursor lesions using balloon and sponge samplers in asymptomatic adults in Linxian, China. Cancer

Roth MJ, Liu SF, Dawsey SM, Zhou B, Copeland C, Wang GQ, Solomon D, Baker SG, Giffen CA, Taylor PR.
Cancer. 80(11): 2047-59, 1997. [ Journal Article ]

Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population

Hu N, Roth MJ, Polymeropolous M, Tang ZZ, Emmert-Buck MR, Wang QH, Goldstein AM, Feng SS, Dawsey SM, Ding T, Zhuang ZP, Han XY, Ried T, Giffen C, Taylor PR.
Genes Chromosomes Cancer. 7(3): 217-28, 2000. [ Journal Article ]

Genetic progression and heterogeneity associated with the development of esophageal squamous cell carcinoma

Roth MJ, Hu N, Emmert-Buck MR, Wang QH, Dawsey SM, Li G, Guo WJ, Zhang YZ, Taylor PR.
Cancer Res. 61(10): 4098-104, 2001. [ Journal Article ]

Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China

Pan QJ, Roth MJ, Guo HQ, Kochman ML, Wang GQ, Henry M, Wei WQ, Giffen CA, Lu N, Abnet CC, Hao CQ, Taylor PR, Qiao YL, Dawsey SM.
Acta Cytol. 52(1): 14-23, 2008. [ Journal Article ]

A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China

Deziel NC, Wei WQ, Abnet CC, Qiao YL, Sunderland D, Ren JS, Schantz MM, Zhang Y, Strickland PT, Abubaker S, Dawsey SM, Friesen MC, Roth MJ.
J Expo Sci Environ Epidemiol. 23(1): 52-9, 2013. [ Journal Article ]