Mark J. Roth, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 2S235K
- Bethesda, MD 20892
- 301-480-7430
- mr166i@nih.gov
RESEARCH SUMMARY
Mark Roth provides routine, daily clinical cytopathology service to the NIH community and teaches anatomic pathology residents and cytopathology fellows in the Laboratory of Pathology, He provides cytology services to support the research endeavors of NIH principal investigators and the Cytopathology Section. He applies his expertise in cytopathology and molecular pathology to develop new approaches to advance the diagnostic, prognostic and therapeutic accuracy of patient samples obtained by minimally invasive techniques such as those used to obtain cytology samples.
Areas of Expertise
Mark J. Roth, M.D.
Research
I apply my expertise in cytopathology and molecular pathology to develop new approaches to advance the diagnostic, prognostic and therapeutic accuracy of patient samples obtained by minimally invasive techniques such as those used to obtain cytology samples. This includes efforts to develop new and adapt existing molecular platforms as signal transduction dysregulation tools for the evaluation of routine clinical cytology samples as part of a clinical support tool that could provide additional diagnostic, therapeutic, and prognostic information.
Publications
Cytologic detection of esophageal squamous cell carcinoma and precursor lesions using balloon and sponge samplers in asymptomatic adults in Linxian, China. Cancer
Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population
Genetic progression and heterogeneity associated with the development of esophageal squamous cell carcinoma
Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China
A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China
Biography
Mark J. Roth, M.D.
I received a Bachelor of Science in Biology from Dickinson College, Carlisle, PA and then attended Temple University School of Medicine in Philadelphia, PA. I completed my residency and fellowship training in Anatomic and Cytologic pathology at the National Institutes of Health (NIH) and related 30-year NIH career as a Commissioned Officer in the Public Health Service, including serving the most recent ten years as an attending for the Cytopathology Section in the Laboratory of Pathology of the National Cancer Institute.
During this period I provided diagnostic interpretation of gynecologic and non-gynecologic cytology samples including fine needle aspirates, interpreted special stains and immunohistochemical stains, performed fine needle aspiration of superficial palpable lesions, and performed rapid-on-site-evaluation for specimen adequacy of fine needle aspirates obtained by radiologists, clinicians and surgeons. In addition to these clinical efforts, I spent 16 years focused on translational and population-based research, during which my efforts were recognized with a Director’s Intramural Innovation Award and becoming a co-inventor and, subsequently, co-patent holder for two inventions.
Through the course of my career I also received the following:
PHS Commendation Award, NCI Certificate of Appreciation for Research Innovation, NCI Director’s Merit Award, PHS Outstanding Unit Citation, PHS Crisis Response Service Award, Outstanding Contribution to the NCI Hurricane Relief Effort, and a PHS Citation in recognition of sustained excellent performance in discovery and early detection on morphologic and molecular markers for cancer.