Lixin Fan, Ph.D.

Lixin Fan, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Structural Biology


Dr. Lixin Fan contributes her expertise in small-angle scattering to the user community of the CCR SAXS Core Facility scientifically and technically. Dr. Fan plays a major role in designing and conducting SAXS/WAXS experiments, data collection, processing, analysis/modeling and interpretation for multi-disciplinary, multi-laboratory collaborations. Dr. Fan also maintains and operates the in-house SAXS instrument, runs necessary equipment at the Advanced Photon Source of Argonne National Laboratory and trains users to operate both the Argonne beamline and the in-house instrument.

Areas of Expertise

1) structural characterization of biomacromolecules and their complexes and soft nanomaterials 2) small-angle X-ray and neutron scattering 3) fluctuation X-ray microscopy 4) coherent X-ray scattering 5) grazing-incidence small-angle scattering transmission/fluorescence scanning X-ray microscopy 6) X-ray phase contrast imaging


Selected Key Publications

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins

Zhang Q, Fan L, Hou F, Dong A, Wang YX, and Tong Y.
Sci Rep. 5: 15660, 2015. [ Journal Article ]

The absolute calibration of a small-angle scattering instrument with a laboratory X-ray source

Fan L, Degen M, Bendle S, Grupido N, and Ilavsky J.
Journal of Physics. 247: 012005, 2010. [ Journal Article ]

Fluctuation X-ray microscopy: a novel approach for structural study of disordered materials

Fan F, Paterson D, McNulty I, Treacy MMJ, and Gibson JM.
J Microsc. 225: 41, 2007. [ Journal Article ]

Structural studies of the 30S subunit of ribosomes Thermus thermophilus by small-angle neutron and X-ray scattering

Fan L, Svergun DI, Volkov VV, Aksenov VL, Algalarov CCh, Selivanova OM, Shcherbakova IV, Koch M, Gilles R, Wiedenmann A, May R, and Serdyuk IN.
J Appl Crystallogr. 33: 515, 2000. [ Journal Article ]

Determination of deuterium incorporation into RNA and protein components of the E.coli ribosome at biosynthetic deuteration by small-angle neutron scattering

Fan L, Zgurskaya EI, and Serdyuk IN.
J Appl Crystallogr. 30: 59, 1997. [ Journal Article ]