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Lisa Ann Ridnour, Ph.D.

Lisa Ann Ridnour, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Ridnour received her Ph.D. under the auspices of the late Dr. Larry Oberley where her work demonstrated that the tumor suppressive effects of MnSOD are mediated, at least in part, by an imbalance in peroxide generating versus peroxide metabolizing enzymes. She completed her postdoctoral training at Washington University in the laboratory of Dr. Douglas Spitz, where she identified thiol-dependent mechanisms associated with NO-induced resistance to peroxide stress. Dr. Ridnour joined the research group of Dr. David Wink (NCI) in 2003. Her research interests include nitric oxide (NO) regulation of extracellular matrix during cancer progression.

Areas of Expertise

1) nitric oxide (NO), 2) NO regulation of extracellular matrix

Publications

Selected Publications

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer

Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.
Breast Cancer Res.. 14: R125, 2012. [ Journal Article ]

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
PLoS ONE. 7: e44156, 2012. [ Journal Article ]

Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation

Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA.
PLoS ONE. 7: e44081, 2012. [ Journal Article ]

NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay

Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA.
Cancer Research. 75/14: 2788-99, 2015. [ Journal Article ]

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

Soto-Pantoja DR, Miller TW, Pendrak ML, Degraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.
Autophagy. 8: 2012. [ Journal Article ]