Lakshmi  Balagopalan, Ph.D.

Lakshmi Balagopalan, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Lakshmi Balagopalan is interested in the molecular events that follow activation of T cells via the T cell antigen receptor (TCR). Dr. Balagopalan is particularly focused on LAT, a molecule that plays a central role in T cell activation downstream of the TCR by directly or indirectly recruiting kinases, effectors, and adaptors to facilitate signal transduction pathways. Specifically, she is interested in mechanisms by which LAT is recruited to sites of T cell activation, and the cellular trafficking itinerary of LAT post-activation.

Areas of Expertise

Signal Transduction
T Cells


Selected Key Publications

Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.
J. Immunol. 190: 3849-53, 2013. [ Journal Article ]

Imaging techniques for assaying lymphocyte activation in action

Balagopalan L, Sherman E, Barr VA, Samelson LE.
Nat Rev Immunol. 11: 21-33, 2011. [ Journal Article ]

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
Proc. Natl. Acad. Sci. U.S.A. 108: 2885-90, 2011. [ Journal Article ]

Endocytic events in TCR signaling: focus on adapters in microclusters

Balagopalan L, Barr VA, Samelson LE.
Immunol. Rev. 232: 84-98, 2009. [ Journal Article ]

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
Mol. Cell. Biol. 27: 8622-36, 2007. [ Journal Article ]