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Kent W. Hunter, Ph.D.

Kent W. Hunter, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Hunter established the paradigm that metastatic progression of breast cancer has a significant inherited component. Using innovative strategies and cutting edge technologies he has identified a number of genes that contribute to inherited susceptibility to tumor dissemination. Dr. Hunter continues to pioneer the use of integrated genetic and genomic technologies to gain better understanding of the genes and cellular pathways that contribute to the metastatic process. Recent efforts include incorporating the knowledge gained from the genetic studies with novel therapeutic compounds or strategies to try to reduce metastatic burden in breast cancer patients.

Areas of Expertise

Publications

Selected Key Publications

Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallels

Rennhack JP, Swiatnicki M, Zhang Y, Caralynn L, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jantissa M, Hunter K, and Andrechek E
Nature Communications. 22: 3261, 2019. [ Journal Article ]

The genomic landscape of metastasis in treatment-naïve breast cancer models

Ross C, Szczepanek K, Lee MP, Yang H, Qiu T, Sanford JD and Hunter KW
PLoS Genetics. 16(5): e1008743, 2020. [ Journal Article ]

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumor recurrence

Vera-Ramirez L, Vodnala S, Nini R, Hunter KW*, and Green JE
Nature Communications. 22: 1944, 2018. [ Journal Article ]

Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1

Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X, Hunter KW.
Nat Genet. 37: 1055-1062, 2005. [ Journal Article ]

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D Tran , Debasish Paul, Steven D Cappell, Sandra Burkett, Huaitian Liu , Maxwell P Lee , Michael J Kruhlak , Jennifer E Dwyer, R Mark Simpson, Gordon L Hager, Yijun Ruan, Kent W Hunter
Nature Communications. 2021.
Full-Text Article
[ Journal Article ]

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Team

Staff Scientist
Christina Ross, Ph.D.
Staff Scientist
Ruhul Amin, Ph.D.
Predoctoral Fellow (CRTA)
Megan Majocha, B.S.
Postdoctoral Fellow
Wan-Ning (Chloe) Li, Ph.D.
Postdoctoral Fellow
Nirupama Kotian, Ph.D.
Postdoctoral Fellow
Xi Chen, Ph.D.
Postbaccalaureate Fellow
Alina Kenina
Biologist
Larry Pearce, B.S.
Biologist
Tinghu Qiu, Ph.D.