Kazi Rahman

Kazi Rahman, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV Dynamics and Replication Program


Kazi obtained a Bachelor of Science from the University of Dhaka in Bangladesh followed by a Master of Science degree from Yamaguchi University in Japan. For his Ph.D. studies, he worked with Dr. Christopher West at the University of Georgia. In 2017, Kazi joined the Compton Lab as a postdoctoral fellow. Here, Kazi uses comparative genomics, cell biology, and virology to describe host-virus interactions, with a focus on characterizing the mechanism of interferon-induced transmembrane (IFITM) proteins. Using an evolution-guided approach, he has discovered novel determinants of IFITM function by taking into account the known activities of related proteins in the CD225 family.  Outside the lab, he likes to read novels, play cricket, and spend time with his family.

Areas of Expertise

1) IFITM 2) influenza 3) membrane fusion 4) evolution 5) genomics


Selected Key Publications

Cholesterol Binds the Amphipathic Helix of IFITM3 and Regulates Antiviral Activity

Kazi Rahman, Siddhartha A K Datta, Andrew H Beaven, Abigail A Jolley, Alexander J Sodt, Alex A Compton
J Mol Biol. 434(19): 2022.
Full-Text Article
[ Journal Article ]

The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes

Kazi Rahman, Alex A Compton
J Virol. 95(21): 2021.
Full-Text Article
[ Journal Article ]

CD225 Proteins: A Family Portrait of Fusion Regulators

Charles A Coomer, Kazi Rahman, Alex A Compton
Trends Genet. 37(5): 406-410, 2021.
Full-Text Article
[ Journal Article ]

Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

Kazi Rahman, Charles A Coomer, Saliha Majdoul, Selena Y Ding, Sergi Padilla-Parra, Alex A Compton.
Elife. 2020.
Full-Text Article
[ Journal Article ]

IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag.

Yadvinder S Ahi, Diborah Yimer, Guoli Shi, Saliha Majdoul, Kazi Rahman, Alan Rein, Alex A Compton
mBio. 2020.
Full-Text Article
[ Journal Article ]